Elastosis

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Author: Mikael Häggström [notes 1]
Elastosis is the buildup of elastin in tissues, and is a form of degenerative disease.[1]

Fixation and gross processing

See skin.

Microscopic evaluation

Consider the main causes of elastosis:

Elastosis causes
Condition Distinctive features Histopathology
Actinic elastosis
(most common, also called solar elastosis)
Elastin replacing collagen fibers of the papillary dermis and reticular dermis.
Because of its high frequency, solar elastosis is often found incidentally with other lesions.
Micrograph of solar elastosis.jpg
Elastosis perforans serpiginosa Degenerated elastic fibers and transepidermal perforating canals (arrow in image points at one of them)[2] Histopathology of elastosis perforans serpiginosa.jpg
Perforating calcific elastosis] Clumping of short elastic fibers in the dermis.[2] Histopathology of perforating calcific elastosis.jpg
Linear focal elastosis Accumulation of fragmented elastotic material within the papillary dermis and transcutaneous elimination of elastotic fibers.[2] Histopathology of linear focal elastosis.jpg

Incidentally discovered elastosis in skin that may have received prolonged sun-exposure can be presumed to be solar elastosis if there are no characteristics of any differential diagnosis thereof.

Reporting

  • The presence of elastosis, with the most probable cause thereof.

In incidentally discovered solar elastosis in case of another disease, description may be brief, such as "Solar elastosis". Optionally, add ", also in surrounding dermis/skin" if present, to emphasize that it is likely not directly connected to the other disease seen.

See also: General notes on reporting

Notes

  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. Beth Wright. Elastosis. DermNet NZ.
  2. 2.0 2.1 2.2 Hosen, Mohammad J.; Lamoen, Anouck; De Paepe, Anne; Vanakker, Olivier M. (2012). "Histopathology of Pseudoxanthoma Elasticum and Related Disorders: Histological Hallmarks and Diagnostic Clues ". Scientifica 2012: 1–15. doi:10.6064/2012/598262. ISSN 2090-908X. 
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