Endoscopic gastrointestinal biopsies

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Author: Mikael Häggström [notes 1]

Endoscopic biopsies   edit
Mostly:

Comprehensiveness

On this resource, the following formatting is used for comprehensiveness:

  • Minimal depth
  • (Moderate depth)
  • ((Comprehensive))

Fixation

Generally 10% neutral buffered formalin.

Gross processing

  • Count the number of fragments. They can be classified as “multiple” at over 5 or 6 specimens. Possibly add “Mixed with luminal material”.
  • Preferably stain with eosin if any fragment is smaller than about 0.3 cm
  • Biopsies that are thicker than about 3-4 mm generally need to be bisected.

Microscopic examination

Example normal reports

Esophagus
(Middle third esophagus, biopsy:)
Squamous mucosa without significant histopathologic changes.
(Negative for eosinophilic esophagitis.)
Gastroesophageal junction
(GE junction, biopsy:)
Squamous mucosa without significant histopathologic changes.
(Negative for gastric mucosa or intestinalized (Barrett's) mucosa.)
Stomach
(Gastric, biopsy:)
Gastric mucosa without significant histopathologic changes.
((Negative for helicobacter pylori organisms on H&E slide.))
Duodenum
(Small bowel, biopsy:)
Duodenal mucosa without significant histopathologic changes.
((Negative for celiac disease.))
Colon
(Colon, biopsy:)
Colonic mucosa without significant histopathologic changes.

Notes

  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

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References