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Author: Mikael Häggström [notes 1]

Inflammation of the stomach:

Microscopy evaluation

Histopathology of mild active gastritis, with intraepithelial neutrophils (white arrows) as well as in lamina propria (black arrows).
  • Mild acute gastritis:[1]
  • Modest edema of lamina propria
  • Vascular congestion
  • Scattered neutrophils
  • Mucosal hemorrhage
  • Intact epithelium
  • Moderate to severe acute gastritis:[1]
  • Loss of superficial epithelium above the muscularis mucosa
  • Hemorrhage
  • Variable infiltrate with neutrophils
  • Fibrinopurulent luminal exudate
  • Nearby epithelium may show regenerative changes
  • Chronic gastritis[2]
Mucosal plasma cell infiltrate in mild chronic gastritis.
  • Presence of plasma cells, lymphocytes, and occasionally lymphoid follicles. Eosinophils and neutrophils may be present.
  • Reduced mucin in the cytoplasm
  • Enlargement of nuclei and nucleoi
  • Subnuclear vacuolation in antral glands or pits (which is PAS negative)
  • Intestinal metaplasia: with partial replacement of the mucosa of the antrum and body with metaplastic goblet cells of intestinal morphology, absorptive cells and Paneth cells.

When gastritis is present, also evaluate as a stomach biopsy for Helicobacter pylori.

Microscopy report

Chronic gastritis without neutrophils is preferably also termed "non-active".


(Gastric, biopsy:) Mild chronic non-active gastritis, non-specific. Negative for Helicobacter pylori organisms on H&E slide.


  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

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  1. 1.0 1.1 Elliot Weisenberg. Stomach - Gastritis - Acute gastritis. pathologyOutlines. Topic Completed: 1 August 2012. Minor changes: 31 August 2020
  2. Elliot Weisenberg. Stomach - Gastritis - Chronic gastritis. PathologyOutlines. Topic Completed: 1 August 2012. Minor changes: 31 August 2020