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Inflammation of the stomach:
- Mild acute gastritis:
- Modest edema of lamina propria
- Vascular congestion
- Scattered neutrophils
- Mucosal hemorrhage
- Intact epithelium
- Moderate to severe acute gastritis:
- Loss of superficial epithelium above the muscularis mucosa
- Variable infiltrate with neutrophils
- Fibrinopurulent luminal exudate
- Nearby epithelium may show regenerative changes
- Chronic gastritis
- Presence of plasma cells, lymphocytes, and occasionally lymphoid follicles. Eosinophils and neutrophils may be present.
- Reduced mucin in the cytoplasm
- Enlargement of nuclei and nucleoi
- Subnuclear vacuolation in antral glands or pits (which is PAS negative)
- Intestinal metaplasia: with partial replacement of the mucosa of the antrum and body with metaplastic goblet cells of intestinal morphology, absorptive cells and Paneth cells.
When gastritis is present, also evaluate as a stomach biopsy for Helicobacter pylori.
Chronic gastritis without neutrophils is preferably also termed "non-active".
|(Gastric, biopsy:) Mild chronic non-active gastritis, non-specific. Negative for Helicobacter pylori organisms on H&E slide.|