Generally 10% neutral buffered formalin.
- See also: General notes on fixation
- Perform consecutive slicing of the entire specimen.
- Look for signs of liposarcoma: Mainly by firm volumes. Color varies from yellow to white (and firm) depending on the proportion of adipocytic, fibrous and/or myxoid content. Areas of fat necrosis are common in larger lesions. Rarely, infiltrative growth is seen.
- Submit slices from any suspicious parts, or at least one representative slice from the specimen.
- Even absence of hemorrhage or necrosis.
|Mass weighing 121 grams and measuring 10 x 6,5 x 3,5 cm. Homogenous yellow color. No hemorrhage or necrosis.|
- See also: General notes on gross processing
Fibrolipoma is a lipoma with focal areas of large amounts of fibrous tissue.
A sclerotic lipoma is one step further: a predominantly fibrous lesion with focal areas of fat.
If unsure of degree of fibrosis: Simply report as lipoma.
Myxoid liposarcoma: Hypercellular solid sheets of cells lying back to back, with round cells or primitive cytomorphology.
A pedunculated lipomatous skin tumor may be a pedunculated lipofibroma:
For lipomas: Absence of signs of malignancy.
Tissue composed of univacuolar fat cells and delicate and inconspicuous fibrous septa. No evidence of malignancy.
- See also: General notes on reporting
- Monica Dahlgren, Janne Malina, Anna Måsbäck, Otto Ljungberg (1997-02-13). Lilla utskärningen.
- Andreas F Mavrogenis, Panayiotis J Papagelopoulos (2013-02-01). Soft Tissues: Well-differentiated liposarcoma. Atlas of Genetics and Cytogenetics in Oncology and Haematology.
- . Lipoma Variant: Fibrolipoma. Stanford University School of Medicine. Retrieved on 2020-02-10.
- Michael R. Clay. Soft tissue - Adipose tissue - Myxoid liposarcoma. PathologyOutlines. Topic Completed: 1 January 2018. Revised: 20 March 2019