Skin chapter
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Author:
Mikael Häggström [notes 1]
For skin specimens in general:
Fixation
Generally 10% neutral buffered formalin.
- See also: General notes on fixation
- Suspected immunologic disease:[1] Fixation for immunofluorescence, with for example Michel's solution.[2] For details, see immunofluorescense of skin tissues
Microscopic evaluation
If the referral does not point to any particular request (see "Most common requests" above), the following algorithm may be applied:
- Is it a suspected malignant skin excision? If not:
- If primarily inflammatory, evaluate as dermatitis. If none of these, evaluate as:
- Benign non-inflammatory skin conditions
Reporting
Preferably see specific articles from algorithm in section above.
- Optionally, the presence of a keratinized squamous epithelium.
- Any abnormalities, generally preceded by location in terms of epidermal, dermal or more specific layers thereof.
- If malignant:
- Degree of differentiation
- Radicality/Least distance to a margin
- Perineural or vascular invasion if present
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Page 678 in: Chhabra, Seema; Minz, RanjanaWalker; Saikia, Biman (2012). "Immunofluorescence in dermatology ". Indian Journal of Dermatology, Venereology, and Leprology 78 (6): 677. doi:. ISSN 0378-6323. Archived from the original. .
- ↑ Katarzyna Lundmark, Krynitz, Ismini Vassilaki, Lena Mölne, Annika Ternesten Bratel. Handläggning av hudprover – provtagningsanvisningar, utskärningsprinciper och snittning (Handling of skin samples - Instructions for sampling, cutting and incision. KVAST (Swedish Society of Pathology). Retrieved on 2019-09-09.
