Skin chapter
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Author:
Mikael Häggström [notes 1]
For skin specimens in general:
Fixation
Generally 10% neutral buffered formalin.
- See also: General notes on fixation
- Suspected immunologic disease:[1] Fixation for immunofluorescence, with for example Michel's solution.[2] For details, see immunofluorescense of skin tissues
Microscopic evaluation
If the referral does not point to any particular request (see "Most common requests" above), the following algorithm may be applied:
- Is it a suspected malignant skin excision? If not:
- If primarily inflammatory, evaluate as dermatitis. If none of these, evaluate as:
- Benign non-inflammatory skin conditions
In intraoperative consultations by frozen section, it is generally sufficient to report clear margins if present, and specification of the type of tumor can be deferred to permanent sections.
Reporting
Preferably see specific articles from algorithm in section above.
- Optionally, the presence of a keratinized squamous epithelium.
- Any abnormalities, generally preceded by location in terms of epidermal, dermal or more specific layers thereof.
- If malignant:
- Degree of differentiation
- Radicality/Least distance to a margin
- Perineural or vascular invasion if present
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Page 678 in: Chhabra, Seema; Minz, RanjanaWalker; Saikia, Biman (2012). "Immunofluorescence in dermatology ". Indian Journal of Dermatology, Venereology, and Leprology 78 (6): 677. doi:. ISSN 0378-6323. Archived from the original. .
- ↑ Katarzyna Lundmark, Krynitz, Ismini Vassilaki, Lena Mölne, Annika Ternesten Bratel. Handläggning av hudprover – provtagningsanvisningar, utskärningsprinciper och snittning (Handling of skin samples - Instructions for sampling, cutting and incision. KVAST (Swedish Society of Pathology). Retrieved on 2019-09-09.
