Stomach biopsy for Helicobacter pylori

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Author: Mikael Häggström [notes 1]

Microscopic evaluation

Helicobacter pylori on HE stain, being curved bacteria in the lumen of a gastric foveola.

Look for:

  • Helicobacter pylori-like bacteria in the lumen, as curved, spirochete-like bacteria, generally in the superficial mucus layer and along microvilli of epithelial cells.[1]
  • Associated inflammation, typically a chronic form of gastritis with germinal centers (follicular gastritis), and plasma cells in lamina propria.[1][notes 2] There should be at least 3 plasma cells facing each other to make a diagnosis of chronic gastritis.

Example report

Chronic gastritis without H. pylori-like organisms should be described as non-specific:

Mild chronic gastritis, which is non-specific.

Negative for H. pylori-like organisms on H&E stain.

Notes

  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
  2. Plasma cells and lymphocytes are normally found in the lamina propria of the small and large intestine, but is abnormal in the stomach.

Main page

References

  1. 1.0 1.1 Elliot Weisenberg. Stomach - Infections - Helicobacter pylori. Pathology Outlines. Topic Completed: 1 August 2012. Minor changes: 1 September 2020