Transfusion reaction

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Author: Mikael Häggström [notes 1]

Immediate management

  • Check if transfusion is ongoing, and if so, stop it until resolution.

Workup

Even for unspecific symptoms, it is essentially never wrong to take blood samples for direct antiglobulin test (DAT) and hemolysis, as well as a urine sample for hemolysis.

Generally request temperature and blood pressure if not already available, and compare with measurements before the transfusion.

Reactions can broadly be classified as follows, where additional symptoms and parameters may point in a different direction:

Transfusion reaction algorithm.jpg

Notes

  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

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References