Urothelial versus squamous cell carcinoma
- As per urinary bladder
- Urothelial carcinoma with squamous differentiation will have some urothelial carcinoma areas and some areas looking like squamous cell carcinoma of the skin.
- Squamous cell carcinoma of the urinary bladder should not have areas appearing like urothelial carcinoma.
In uncertain cases, perform immunohistochemistry for S100P and GATA3, where positivity indicates urothelial carcinomas with squamous differentiation (positive in 83% and 35% respectively), and negativity indicates squamous cell carcinomas (positive in 9% and near-0%, respectively).
- Gulmann, Christian; Paner, Gladell P.; Parakh, Rugvedita S.; Hansel, Donna E.; Shen, Steven S.; Ro, Jae Y.; Annaiah, Chandrakanth; Lopez-Beltran, Antonio; et al. (2013). "Immunohistochemical profile to distinguish urothelial from squamous differentiation in carcinomas of urothelial tract ". Human Pathology 44 (2): 164–172. doi:10.1016/j.humpath.2012.05.018. ISSN 00468177.