Verrucous oral lesions
Verrucous oral lesions have hypergranulosis and/or hyperkeratosis as the most conspicuous finding.
Look for signs of koilocyte-like changes, which may indicate verrucous squamous cell carcinoma, and which typically only has low atypia:
Verrucous squamous cell carcinoma (images are from penis).
If uncertain, perform immunohistochemistry for Ki67 and p53.
- Initially copied from: Paolino, Giovanni; Donati, Michele; Didona, Dario; Mercuri, Santo; Cantisani, Carmen (2017). "Histology of Non-Melanoma Skin Cancers: An Update ". Biomedicines 5 (4): 71. doi:10.3390/biomedicines5040071. ISSN 2227-9059. - "This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."