Difference between revisions of "Benign non-inflammatory skin conditions"

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==Fixation==
 
==Fixation==
 
{{Skin fixation, minimal}}
 
{{Skin fixation, minimal}}
−
{{Gross processing of skin excisions}}
+
{{Gross processing of skin lesions with benign appearance}}
 
==Microscopic evaluation==
 
==Microscopic evaluation==
 
The primary objective is to determine the location, and then the most likely cell type of the aberration:
 
The primary objective is to determine the location, and then the most likely cell type of the aberration:

Revision as of 10:43, 11 December 2019

Author: Mikael Häggström [note 1]
These are aberrations that do not display signs of suspected malignant excisions or dermatitis:

Fixation

  • Generally: Buffered 4% formaldehyde.[1]

Gross processing

Gross pathology processing of skin lesions with benign appearance, by lesion size:[2]
<4 mm 4 - 8 mm 9 - 15 mm

Tissue selection from skin excision with lesion less than 4 mm with benign appearance.png

Tissue selection from skin excision with lesion 4-8 mm with benign appearance.png

Tissue selection from skin excision with lesion 9-15 mm with benign appearance.png

In table above, each top image shows recommended lines for cutting out slices to be submitted for further processing. Bottom image shows which side of the slice that should be put to microtomy. Dashed lines here mean that either side could be used. Further information: Gross processing of skin excisions

Microscopic evaluation

The primary objective is to determine the location, and then the most likely cell type of the aberration:

Dermis

Sebaceous glands

  • Sebaceous hyperplasia: Multiple, mature sebaceous lobules attached to the central dilated duct in the upper dermis.[3]

Fatty tissue

  • Lipoma: The mass is composed of lobules of mature white adipose tissue divided by delicate and inconspicuous fibrous septa containing thin-walled capillary-sized vessels.[4]

Notes

  1. ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. ↑ Katarzyna Lundmark, Krynitz, Ismini Vassilaki, Lena Mölne, Annika Ternesten Bratel. Handläggning av hudprover – provtagningsanvisningar, utskärningsprinciper och snittning (Handling of skin samples - Instructions for sampling, cutting and incision. KVAST (Swedish Society of Pathology). Retrieved on 2019-09-09.
  2. ↑ ". Ochsner J 5 (2): 22–33. 2003. PMID 22826680. PMC: 3399331. Archived from the original. . 
    - With a "standard histologic examination" that, in addition to the lesion, only includes one section from each side along the longest diameter of the specimen.
    - It also shows an example of circular coverage, with equal coverage distance in all four directions.
    - The entire specimen may be submitted if the risk of malignancy is high.
  3. ↑ Sato, Toshitsugu; Tanaka, Masaru (2014). "Linear sebaceous hyperplasia on the chest ". Dermatology Practical & Conceptual. doi:10.5826/dpc.0401a16. ISSN 21609381. 
  4. ↑ Kim, Hei Sung  (2016). "Lipoma on the antitragus of the ear ". Journal of Clinical Research in Dermatology 3 (2): 01–02. doi:10.15226/2378-1726/3/2/00121. ISSN 23781726. 

Image sources


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