Borderline tumor
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Author:
Mikael Häggström [note 1]
Contents
Gross processing
Depending on presentation:
Microscopic evaluation
Seromucinous borderline tumors; microscopic pictures showing a variety of cell types.
(a) Sometimes mucinous cells with voluminous cytoplasm can mimic goblet cells. Admixed lightly eosinophilic ciliated cells are almost always identifiable.
(b) Background of prominent neutrophilic infiltration. Admixture of mucinous cells, eosinophilic cells, and some clear cells, with mild or moderate nuclear atypia and stratifications.
(c) Indifferent cells with abundant eosinophilic cytoplasm.
(d) Endometrioid type epithelium.
(e) Squamous epithelium.
(f) Clear cells. Focal hobnail appearance is also seen (right lower corner).[1]
(a) Sometimes mucinous cells with voluminous cytoplasm can mimic goblet cells. Admixed lightly eosinophilic ciliated cells are almost always identifiable.
(b) Background of prominent neutrophilic infiltration. Admixture of mucinous cells, eosinophilic cells, and some clear cells, with mild or moderate nuclear atypia and stratifications.
(c) Indifferent cells with abundant eosinophilic cytoplasm.
(d) Endometrioid type epithelium.
(e) Squamous epithelium.
(f) Clear cells. Focal hobnail appearance is also seen (right lower corner).[1]
Exclude other causes of tumor or cyst. Further information: Ovarian tumor and Ovarian cyst
Typical features of an ovarian serous borderline tumor: Hierarchical branching, exfoliated cell clusters, calcifications, up to moderate atypia, and pseudostratified, crowded epithelium with hobnailing.[image 1]
Borderline tumors may have non-invasive invaginations as shown. Otherwise, invasion renders a diagnosis of ovarian cancer
Microscopic report
Include at least:
- The diagnosis of an ovarian borderline tumor, with subtyping of serous versus mucinous if applicable
- Size
Example:
| Left ovary, oophorectomy: Ovarian serous borderline tumor (9.1 cm). |
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Nagamine M, Mikami Y (2020). "Ovarian Seromucinous Tumors: Pathogenesis, Morphologic Spectrum, and Clinical Issues.
". Diagnostics 10 (2): 77. doi:. PMID 32023964.
- "This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."
Image sources
- ↑ Image(s) by: Mikael Häggström, M.D. Public Domain
- Author info
- Reusing images
