Clear cell renal cell carcinoma
Author:
Mikael Häggström [note 1]
Clear cell renal cell carcinoma (CCRCC):
Contents
Gross processing
As per: Kidney with tumor
Microscopic examination
CCRCC typically shows cells in nests or solid pattern, and a delicate branching fibrovascular network.[1]
Differential diagnosis: Kidney with tumor
If unsure, useful immunohistochemistry markers that are positive in CCRCC are vimentin, EMA, keratin, CD10, Pax2, RCC, CAIX (circumferential membranous).[1]
Grading
CCRCCs are graded by the ISUP/WHO as follows:[2][3]
- Grade 1: Inconspicuous and basophilic nucleoli at ×400 magnification
- Grade 4: Extreme pleomorphism or rhabdoid and/or sarcomatoid morphology
Microscopy report
- Diagnosis of clear cell renal cell carcinoma
- Greatest dimension (from grossing)
- ISUP/WHO grade
- Radicality
Example:
Kidney, left, partial nephrectomy:
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Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ 1.0 1.1 Sirohi, Deepika; Smith, Steven C.; Agarwal, Neeraj; Maughan, Benjamin L. (2018). "Unclassified renal cell carcinoma: diagnostic difficulties and treatment modalities ". Research and Reports in Urology Volume 10: 205–217. doi: . ISSN 2253-2447.
- ↑ YiFen Zhang. What is the ISUP/WHO grading system for renal cell carcinoma (RCC)?. Medscape. Updated: Jul 02, 2019
- ↑ Moch, H. (2016). "WHO-ISUP-Graduierungssystem für Nierenkarzinome ". Der Pathologe 37 (4): 355–360. doi: . ISSN 0172-8113.
Image sources