Difference between revisions of "Eosinophilic esophagitis"

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==Microscopic diagnosis==
 
==Microscopic diagnosis==
 
[[File:Micrograph of eosinophilic esophagitis.jpg|thumb|Eosinophilic infiltrate. In this case also intercellular edema giving a spongy appearance.]]
 
[[File:Micrograph of eosinophilic esophagitis.jpg|thumb|Eosinophilic infiltrate. In this case also intercellular edema giving a spongy appearance.]]
A prominent eosinophilic infiltrate, with consensus guidelines defining it as over 15 eosinophils per HPF.<ref name="Dellon2012">{{cite journal|last1=Dellon|first1=Evan S.|title=Eosinophilic esophagitis|journal=Current Opinion in Gastroenterology|volume=28|issue=4|year=2012|pages=382–388|issn=0267-1379|doi=10.1097/MOG.0b013e328352b5ef}}</ref>
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It is characterized by a prominent eosinophilic infiltrate in the [[esophagus]], with consensus guidelines defining it as over 15 eosinophils per HPF.<ref name="Dellon2012">{{cite journal|last1=Dellon|first1=Evan S.|title=Eosinophilic esophagitis|journal=Current Opinion in Gastroenterology|volume=28|issue=4|year=2012|pages=382–388|issn=0267-1379|doi=10.1097/MOG.0b013e328352b5ef}}</ref>
  
 
==Report==
 
==Report==
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:*Number of eosinophils per HPF
 
:*Number of eosinophils per HPF
  
;Example in an unremarkable case:
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In borderline cases, such as an incidental finding of eosinophils at around 15/HPF, a separate explanatory comment can be made, such as:
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{|class=wikitable
 
{|class=wikitable
| (Optionally: Squamous mucosa, negative for significant histopathologic changes.) Negative for significant eosinophilia.
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| (Esophagus, biopsy:)<br>Squamous mucosa with increased intraepithelial eosinophils of up to 15/HPF. See comment.
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''Comment: There is no evidence of eosinophilic microabscesses.  Although this may represent reflux esophagitis, a diagnosis of eosinophilic esophagitis is considered in the correct clinical setting.''
 
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|}
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{{Bottom}}
 
{{Bottom}}

Revision as of 15:10, 1 December 2020

Author: Mikael Häggström [note 1]

Microscopic diagnosis

Eosinophilic infiltrate. In this case also intercellular edema giving a spongy appearance.

It is characterized by a prominent eosinophilic infiltrate in the esophagus, with consensus guidelines defining it as over 15 eosinophils per HPF.[1]

Report

  • If positive:
  • Presence of eosinophilic esophagitis
  • Number of eosinophils per HPF

In borderline cases, such as an incidental finding of eosinophils at around 15/HPF, a separate explanatory comment can be made, such as:

(Esophagus, biopsy:)
Squamous mucosa with increased intraepithelial eosinophils of up to 15/HPF. See comment.

Comment: There is no evidence of eosinophilic microabscesses. Although this may represent reflux esophagitis, a diagnosis of eosinophilic esophagitis is considered in the correct clinical setting.

Notes

  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. Dellon, Evan S. (2012). "Eosinophilic esophagitis ". Current Opinion in Gastroenterology 28 (4): 382–388. doi:10.1097/MOG.0b013e328352b5ef. ISSN 0267-1379. 

Image sources