Difference between revisions of "Eosinophilic esophagitis"
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[[File:Micrograph of eosinophilic esophagitis.jpg|thumb|Eosinophilic infiltrate. In this case also intercellular edema giving a spongy appearance.]] | [[File:Micrograph of eosinophilic esophagitis.jpg|thumb|Eosinophilic infiltrate. In this case also intercellular edema giving a spongy appearance.]] | ||
It is characterized by a prominent eosinophilic infiltrate in the [[esophagus]], with consensus guidelines defining it as over intra-epithelial 15 eosinophils per HPF.<ref name="Dellon2012">{{cite journal|last1=Dellon|first1=Evan S.|title=Eosinophilic esophagitis|journal=Current Opinion in Gastroenterology|volume=28|issue=4|year=2012|pages=382–388|issn=0267-1379|doi=10.1097/MOG.0b013e328352b5ef}}</ref> | It is characterized by a prominent eosinophilic infiltrate in the [[esophagus]], with consensus guidelines defining it as over intra-epithelial 15 eosinophils per HPF.<ref name="Dellon2012">{{cite journal|last1=Dellon|first1=Evan S.|title=Eosinophilic esophagitis|journal=Current Opinion in Gastroenterology|volume=28|issue=4|year=2012|pages=382–388|issn=0267-1379|doi=10.1097/MOG.0b013e328352b5ef}}</ref> | ||
| − | + | <ref group=notes>It has also been described as ≥15 intraepithelial eosinophils in ≥2 hpfs or ≥25 in any single hpf.<br> - {{cite journal|last1=Parfitt|first1=Jeremy R|last2=Gregor|first2=James C|last3=Suskin|first3=Neville G|last4=Jawa|first4=Hani A|last5=Driman|first5=David K|title=Eosinophilic esophagitis in adults: distinguishing features from gastroesophageal reflux disease: a study of 41 patients|journal=Modern Pathology|volume=19|issue=1|year=2005|pages=90–96|issn=0893-3952|doi=10.1038/modpathol.3800498}}</ref> | |
| + | <gallery> | ||
File:Histology of an eosinophil in esophageal epithelium.jpg|thumb|180px|An intra-epithelial '''eosinophil''' (characterized by its bilobed nucleus despite scant visible eosinophilic cytoplasm) | File:Histology of an eosinophil in esophageal epithelium.jpg|thumb|180px|An intra-epithelial '''eosinophil''' (characterized by its bilobed nucleus despite scant visible eosinophilic cytoplasm) | ||
</gallery> | </gallery> | ||
Revision as of 15:20, 1 December 2020
Author:
Mikael Häggström [note 1]
Microscopic diagnosis
It is characterized by a prominent eosinophilic infiltrate in the esophagus, with consensus guidelines defining it as over intra-epithelial 15 eosinophils per HPF.[1] [notes 1]
An intra-epithelial eosinophil (characterized by its bilobed nucleus despite scant visible eosinophilic cytoplasm)
Report
- If positive:
- Presence of eosinophilic esophagitis
- Number of eosinophils per HPF
In borderline cases, such as an incidental finding of eosinophils at around 15/HPF, a separate explanatory comment can be made, such as:
| (Esophagus, biopsy:) Squamous mucosa with increased intraepithelial eosinophils of up to 15/HPF. See comment. ... Comment: There is no evidence of eosinophilic microabscesses. Although this may represent reflux esophagitis, a diagnosis of eosinophilic esophagitis is considered in the correct clinical setting. |
Notes
- ↑ It has also been described as ≥15 intraepithelial eosinophils in ≥2 hpfs or ≥25 in any single hpf.
- Parfitt, Jeremy R; Gregor, James C; Suskin, Neville G; Jawa, Hani A; Driman, David K (2005). "Eosinophilic esophagitis in adults: distinguishing features from gastroesophageal reflux disease: a study of 41 patients ". Modern Pathology 19 (1): 90–96. doi:. ISSN 0893-3952.
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
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References
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