Eosinophilic esophagitis
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Author:
Mikael Häggström [note 1]
Microscopic diagnosis
It is characterized by a prominent eosinophilic infiltrate in the esophagus, with consensus guidelines defining it as over intra-epithelial 15 eosinophils per HPF.[1] [notes 1]
Report
- If positive:
- Presence of eosinophilic esophagitis
- Number of eosinophils per HPF
In borderline cases, such as an incidental finding of eosinophils at around 15/HPF, a separate explanatory comment can be made, such as:
(Esophagus, biopsy:) Squamous mucosa with increased intraepithelial eosinophils of up to 15/HPF. See comment. ... Comment: There is no evidence of eosinophilic microabscesses. Although this may represent reflux esophagitis, a diagnosis of eosinophilic esophagitis is considered in the correct clinical setting. |
Notes
- ↑ It has also been described as ≥15 intraepithelial eosinophils in ≥2 hpfs or ≥25 in any single hpf.
- Parfitt, Jeremy R; Gregor, James C; Suskin, Neville G; Jawa, Hani A; Driman, David K (2005). "Eosinophilic esophagitis in adults: distinguishing features from gastroesophageal reflux disease: a study of 41 patients ". Modern Pathology 19 (1): 90–96. doi: . ISSN 0893-3952.
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
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