Difference between revisions of "Gastritis"

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Inflammation of the [[stomach]]:
 
Inflammation of the [[stomach]]:
 
==Microscopy evaluation==
 
==Microscopy evaluation==
[[File:Histopathology of mild active gastritis, annotated.jpg|thumb|Histopathology of mild active gastritis, with intraepithelial neutrophils (white arrows) as well as in lamina propria (black arrows).]]
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[[File:Histopathology of mild active gastritis, annotated.jpg|thumb|Histopathology of '''mild active gastritis''', with intraepithelial neutrophils (white arrows) as well as in lamina propria (black arrows).]]
 
*'''Mild acute gastritis:'''<ref name=PathologyOutlinesAcute>{{cite web|url=https://www.pathologyoutlines.com/topic/stomachacutegastritis.html|title=Stomach - Gastritis - Acute gastritis|author=Elliot Weisenberg|website=pathologyOutlines}} Topic Completed: 1 August 2012. Minor changes: 31 August 2020</ref>
 
*'''Mild acute gastritis:'''<ref name=PathologyOutlinesAcute>{{cite web|url=https://www.pathologyoutlines.com/topic/stomachacutegastritis.html|title=Stomach - Gastritis - Acute gastritis|author=Elliot Weisenberg|website=pathologyOutlines}} Topic Completed: 1 August 2012. Minor changes: 31 August 2020</ref>
 
:*Modest '''edema''' of lamina propria
 
:*Modest '''edema''' of lamina propria
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:*Nearby epithelium may show '''regenerative''' changes
 
:*Nearby epithelium may show '''regenerative''' changes
 
*'''Chronic gastritis'''<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/stomachchronicgastritis.html|title=Stomach - Gastritis - Chronic gastritis|author=Elliot Weisenberg|website=PathologyOutlines}} Topic Completed: 1 August 2012. Minor changes: 31 August 2020</ref>
 
*'''Chronic gastritis'''<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/stomachchronicgastritis.html|title=Stomach - Gastritis - Chronic gastritis|author=Elliot Weisenberg|website=PathologyOutlines}} Topic Completed: 1 August 2012. Minor changes: 31 August 2020</ref>
[[File:Histopathology of mucosal plasma cell infiltrate in chronic gastritis.jpg|thumb|Mucosal plasma cell infiltrate in mild chronic gastritis.]]
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[[File:Histopathology of mucosal plasma cell infiltrate in chronic gastritis.jpg|thumb|Mucosal plasma cell infiltrate in '''mild chronic gastritis'''.]]
 
:*Presence of '''plasma cells''', '''lymphocytes''', and occasionally lymphoid '''follicles'''. Eosinophils and neutrophils may be present.  
 
:*Presence of '''plasma cells''', '''lymphocytes''', and occasionally lymphoid '''follicles'''. Eosinophils and neutrophils may be present.  
 
:*'''Reduced mucin''' in the cytoplasm
 
:*'''Reduced mucin''' in the cytoplasm

Revision as of 15:53, 1 December 2020

Author: Mikael Häggström [note 1]

Inflammation of the stomach:

Microscopy evaluation

Histopathology of mild active gastritis, with intraepithelial neutrophils (white arrows) as well as in lamina propria (black arrows).
  • Mild acute gastritis:[1]
  • Modest edema of lamina propria
  • Vascular congestion
  • Scattered neutrophils
  • Mucosal hemorrhage
  • Intact epithelium
  • Moderate to severe acute gastritis:[1]
  • Loss of superficial epithelium above the muscularis mucosa
  • Hemorrhage
  • Variable infiltrate with neutrophils
  • Fibrinopurulent luminal exudate
  • Nearby epithelium may show regenerative changes
  • Chronic gastritis[2]
Mucosal plasma cell infiltrate in mild chronic gastritis.
  • Presence of plasma cells, lymphocytes, and occasionally lymphoid follicles. Eosinophils and neutrophils may be present.
  • Reduced mucin in the cytoplasm
  • Enlargement of nuclei and nucleoi
  • Subnuclear vacuolation in antral glands or pits (which is PAS negative)
  • Intestinal metaplasia: with partial replacement of the mucosa of the antrum and body with metaplastic goblet cells of intestinal morphology, absorptive cells and Paneth cells.

When gastritis is present, also evaluate as a stomach biopsy for Helicobacter pylori.

Microscopy report

Chronic gastritis without neutrophils is preferably also termed "non-active".

Example:

(Gastric, biopsy:) Mild chronic non-active gastritis, non-specific. Negative for Helicobacter pylori organisms on H&E slide.

Notes

  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. 1.0 1.1 Elliot Weisenberg. Stomach - Gastritis - Acute gastritis. pathologyOutlines. Topic Completed: 1 August 2012. Minor changes: 31 August 2020
  2. Elliot Weisenberg. Stomach - Gastritis - Chronic gastritis. PathologyOutlines. Topic Completed: 1 August 2012. Minor changes: 31 August 2020

Image sources