Squamous-cell carcinoma

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Author: Mikael Häggström [note 1]
Squamous-cell carcinoma (SCC):

Locations

Use the location-specific article when applicable:

Microscopic evaluation

To support the diagnosis of a suspected squamous-cell carcinoma, immunohistochemistry can be used, including p63 and p40.

Degree of differentiation

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Cytology

Cytopathology of squamous cell carcinoma, nonkeratinizing variant, with typical features.[2] Pap stain. For a case of a case of high-grade squamous intraepithelial lesion, necrotic debris (dirty background) is a feature that generally makes the case "suspicious for invasive squamous cell carcinoma".[3] In contrast to the more distinct keratinizing variant, these findings are overall less specific, and most can be seen in other cancers such as adenocarcinoma as well (which, however, tends to have fine chromatin)[4]

Further workup

Immunohistochemistry for p16 highly correlates with HPV infection, and is indicated mainly in cervical dysplasia, but also in SCC of other sites where HPV infection is more or less frequently implicated, including vagina, vulva, penis, anus, tonsil and other oropharyngeal locations.[6]

Notes

  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. 1.0 1.1 1.2 Yanofsky, Valerie R.; Mercer, Stephen E.; Phelps, Robert G. (2011). "Histopathological Variants of Cutaneous Squamous Cell Carcinoma: A Review ". Journal of Skin Cancer 2011: 1–13. doi:10.1155/2011/210813. ISSN 2090-2905. .
    -"This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."
  2. - Image annotated by Mikael Häggström
    - Reference for entries: Gulisa Turashvili, M.D., Ph.D.. Cervix - Squamous cell carcinoma and variants. Pathology Outlines. Last author update: 24 September 2020. Last staff update: 4 April 2022.
    - Source image by Ravi Mehrotra, Anurag Gupta, Mamta Singh and Rahela Ibrahim (Creative Commons Attribution 2.0 Generic license.)
  3. Alrajjal A, Pansare V, Choudhury MSR, Khan MYA, Shidham VB (2021). "Squamous intraepithelial lesions (SIL: LSIL, HSIL, ASCUS, ASC-H, LSIL-H) of Uterine Cervix and Bethesda System. ". Cytojournal 18: 16. doi:10.25259/Cytojournal_24_2021. PMID 34345247. PMC: 8326095. Archived from the original. . 
  4. Authors: Caroline I.M. Underwood, M.D., Alexis Musick, B.S., Carolyn Glass, M.D., Ph.D.. Adenocarcinoma overview. Pathology Outlines. Last staff update: 19 July 2022
  5. - Image annotated by Mikael Häggström
    - Reference for entries: Gulisa Turashvili, M.D., Ph.D.. Cervix - Squamous cell carcinoma and variants. Pathology Outlines. Last author update: 24 September 2020. Last staff update: 4 April 2022.
    - Source image from National Cancer Institute (Public Domain)
  6. Erika M. Baardsen, D.O., Marilin Rosa, M.D.. Cervix - Premalignant / preinvasive lesions - H&E - HPV. Pathology Outlines. Last author update: 1 December 2017. Last staff update: 5 May 2021

Image sources