Difference between revisions of "Template:Overlap of squamous-cell and basal-cell carcinoma"
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Yet, a high prevalence means a relatively high incidence of borderline cases, with main forms being: | Yet, a high prevalence means a relatively high incidence of borderline cases, with main forms being: | ||
<gallery mode=packed heights=200> | <gallery mode=packed heights=200> | ||
| − | File:BCC with squamous cell metaplasia | + | File:BCC with squamous cell metaplasia.jpg|'''Basal-cell carcinoma with squamous cell metaplasia''' or metatypical (squamoid) basal-cell carcinoma. |
File:Histopathology of basaloid squamous cell carcinoma.png|'''Basaloid squamous-cell carcinoma''', in this case showing a biphasic pattern with conventional dysplastic squamous surface component associated with basaloid elements (arrow heads) and conventional squamous cell carcinoma intimately associated with basaloid component (arrow).<ref>{{cite journal|last1=El-Mofty|first1=SK.|title=Histopathologic risk factors in oral and oropharyngeal squamous cell carcinoma variants: An update with special reference to HPV-related carcinomas|journal=Medicina Oral Patología Oral y Cirugia Bucal|year=2014|pages=e377–e385|issn=16986946|doi=10.4317/medoral.20184}}<br>License: CC BY 2.5</ref> | File:Histopathology of basaloid squamous cell carcinoma.png|'''Basaloid squamous-cell carcinoma''', in this case showing a biphasic pattern with conventional dysplastic squamous surface component associated with basaloid elements (arrow heads) and conventional squamous cell carcinoma intimately associated with basaloid component (arrow).<ref>{{cite journal|last1=El-Mofty|first1=SK.|title=Histopathologic risk factors in oral and oropharyngeal squamous cell carcinoma variants: An update with special reference to HPV-related carcinomas|journal=Medicina Oral Patología Oral y Cirugia Bucal|year=2014|pages=e377–e385|issn=16986946|doi=10.4317/medoral.20184}}<br>License: CC BY 2.5</ref> | ||
| − | </gallery><noinclude> | + | </gallery> |
| + | |||
| + | In unclear cases, the most useful immunohistochemistry marker appears to be '''MOC-31''', which essentially always stains metatypical basal-cell carcinomas but not basaloid squamous-cell carcinomas.<ref name="WebbMentrikoski2015">{{cite journal|last1=Webb|first1=David V.|last2=Mentrikoski|first2=Mark J.|last3=Verduin|first3=Lindsey|last4=Brill|first4=Louis B.|last5=Wick|first5=Mark R.|title=Basal cell carcinoma vs basaloid squamous cell carcinoma of the skin: an immunohistochemical reappraisal|journal=Annals of Diagnostic Pathology|volume=19|issue=2|year=2015|pages=70–75|issn=10929134|doi=10.1016/j.anndiagpath.2015.01.004}}</ref> '''UEA-1''' appears to be the second most useful marker, staining almost all basaloid squamous-cell carcinomas but only a few metatypical basal-cell carcinomas.<ref name="WebbMentrikoski2015"/><noinclude> | ||
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Revision as of 18:28, 2 July 2020
Author:
Mikael Häggström [note 1]
Yet, a high prevalence means a relatively high incidence of borderline cases, with main forms being:
Basal-cell carcinoma with squamous cell metaplasia or metatypical (squamoid) basal-cell carcinoma.
Basaloid squamous-cell carcinoma, in this case showing a biphasic pattern with conventional dysplastic squamous surface component associated with basaloid elements (arrow heads) and conventional squamous cell carcinoma intimately associated with basaloid component (arrow).[1]
In unclear cases, the most useful immunohistochemistry marker appears to be MOC-31, which essentially always stains metatypical basal-cell carcinomas but not basaloid squamous-cell carcinomas.[2] UEA-1 appears to be the second most useful marker, staining almost all basaloid squamous-cell carcinomas but only a few metatypical basal-cell carcinomas.[2]
Contents
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ El-Mofty, SK. (2014). "Histopathologic risk factors in oral and oropharyngeal squamous cell carcinoma variants: An update with special reference to HPV-related carcinomas
". Medicina Oral Patología Oral y Cirugia Bucal: e377–e385. doi:. ISSN 16986946.
License: CC BY 2.5 - ↑ 2.0 2.1 Webb, David V.; Mentrikoski, Mark J.; Verduin, Lindsey; Brill, Louis B.; Wick, Mark R. (2015). "Basal cell carcinoma vs basaloid squamous cell carcinoma of the skin: an immunohistochemical reappraisal ". Annals of Diagnostic Pathology 19 (2): 70–75. doi:. ISSN 10929134.
Image sources
