Difference between revisions of "Template:Squamous-cell like skin proliferations - differential diagnosis"
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File:Micrograph of squamous cell carcinoma in situ - 100x.jpg|'''[[Squamous-cell carcinoma of the skin|Squamous-cell carcinoma ''in situ'' (Bowen’s disease)]]''': Atypical keratinocytes at every layer of epidermis. | File:Micrograph of squamous cell carcinoma in situ - 100x.jpg|'''[[Squamous-cell carcinoma of the skin|Squamous-cell carcinoma ''in situ'' (Bowen’s disease)]]''': Atypical keratinocytes at every layer of epidermis. | ||
File:Micrograph of actinic keratosis - low magnification.jpg|'''[[Actinic keratosis]]''': Atypical keratinocytes that do not span the full thickness of the epidermis (or, in Bowenoid variant, are less disordered with less nuclear atypia and crowding). | File:Micrograph of actinic keratosis - low magnification.jpg|'''[[Actinic keratosis]]''': Atypical keratinocytes that do not span the full thickness of the epidermis (or, in Bowenoid variant, are less disordered with less nuclear atypia and crowding). | ||
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File:Keratoacanthoma (2197016163).jpg|'''Keratoacanthoma''': Symmetrical and circumscribed proliferation of keratinocytes, with central horn plug, with epidermis that extends over the tumor. It can be regarded as a highly differentiated SCC. | File:Keratoacanthoma (2197016163).jpg|'''Keratoacanthoma''': Symmetrical and circumscribed proliferation of keratinocytes, with central horn plug, with epidermis that extends over the tumor. It can be regarded as a highly differentiated SCC. | ||
File:Skin with folds and crush artifact by needle.jpg|'''Crush artifacts''': Needles used to orient the skin sample may create crush artifacts (black arrow) mimicking cellular atypia with mainly hypereosinophilia and nuclear pleomorphism. Image also shows folding artifacts (white arrows). | File:Skin with folds and crush artifact by needle.jpg|'''Crush artifacts''': Needles used to orient the skin sample may create crush artifacts (black arrow) mimicking cellular atypia with mainly hypereosinophilia and nuclear pleomorphism. Image also shows folding artifacts (white arrows). | ||
Revision as of 17:16, 2 July 2020
Author:
Mikael Häggström [note 1]
Contents
Squamous cell-like skin proliferations: Differential diagnosis
Main differential diagnoses and their characteristics:[1]
Invasive squamous-cell carcinoma of the skin: Atypical and pleomorphic keratinocytes, involving the dermis and the sub-cutis with a potential metastatic spread.
Squamous-cell carcinoma in situ (Bowen’s disease): Atypical keratinocytes at every layer of epidermis.
Actinic keratosis: Atypical keratinocytes that do not span the full thickness of the epidermis (or, in Bowenoid variant, are less disordered with less nuclear atypia and crowding).
Keratoacanthoma: Symmetrical and circumscribed proliferation of keratinocytes, with central horn plug, with epidermis that extends over the tumor. It can be regarded as a highly differentiated SCC.
Crush artifacts: Needles used to orient the skin sample may create crush artifacts (black arrow) mimicking cellular atypia with mainly hypereosinophilia and nuclear pleomorphism. Image also shows folding artifacts (white arrows).
Adnexal carcinomas: Squamous differentiation, but does not show connection with the epidermis and highlights adnexal features.
Adenosquamous carcinoma: Mixed glandular and squamous differentiation.
Verrucous squamous cell carcinoma[notes 1]: Exophytic squamous proliferation with marked papillomatosis and low atypia and the presence of koilocyte-like changes. Found in head and neck locations, as well as in the genitalia and sole of the foot.
Inverted follicular keratosis:[notes 2]: Sharply circumscribed endophytic verrucous proliferation with prominent squamous features.
Seborrheic keratosis: Acanthosis, absence of atypia, pseudo-horn cysts, in inflamed lesions, mitoses may be present.
Bowenoid papulosis: Atypical keratinocytes and mitoses. Histology similar to Bowen’s disease.
Metastasis: Personal medical history of the patient, nodular proliferation without connection to epidermis, immunohistochemical evaluation. Squamous-cell carcinoma metastasis from lungs to the skin is pictured.
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Notes
- ↑ - Buschke–Löwenstein tumor is an alternative name for verrucous squamous cell carcinoma in the ano-genital region.
- Carcinoma cuniculatum is a characteristic form of verrucous squamous cell carcinoma on the sole. - ↑ Inverted follicular keratosis is generally thought to be a rare variant of seborrheic keratosis, but this position is not universally accepted.
- Karadag, AyseSerap; Ozlu, Emin; Uzuncakmak, TugbaKevser; Akdeniz, Necmettin; Cobanoglu, Bengu; Oman, Berkant (2016). "Inverted follicular keratosis successfully treated with imiquimod ". Indian Dermatology Online Journal 7 (3): 177. doi:. ISSN 2229-5178.
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Initially copied from: Paolino, Giovanni; Donati, Michele; Didona, Dario; Mercuri, Santo; Cantisani, Carmen (2017). "Histology of Non-Melanoma Skin Cancers: An Update ". Biomedicines 5 (4): 71. doi:. ISSN 2227-9059. - "This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."
Image sources
