Template:Table comparing congenital nevus, dysplastic nevus and suspected melanoma
Parameter | Non-atypical congenital pattern | Low-grade dysplastic nevus | High-grade dysplastic nevus | Suspected melanoma in situ | ||
---|---|---|---|---|---|---|
Mild dysplasia | Moderate dysplasia | Severe dysplasia | ||||
Macroscopic | Lateral circumscription[1] | Sharp | Slightly diminished | Moderate | Poor | |
Symmetry[1] | Good | Often broken | Rare | |||
Structural (Low mag.) |
Delimitation[2] | Rarely diffuse | Sometimes diffuse | Often diffuse | ||
Lentiginous proliferation[notes 1][2] | Yes, along with rete pegs | Yes, along with and focally between rete pegs | Yes, along with and focally between rete pegs | Yes partially continuous, multilayered | ||
Bridging[2] | Rarely | Often | ||||
Confluent nests[2] | Rarely | Sometimes | Often | Often widespread | ||
Pigment distribution[2] | Regular | Irregular | ||||
Suprabasal presence (less than most superficial third of epidermis) | Occasionally centrally[1] | No[2] or rarely[1] | Occasionally centrally[1] | Yes, multifocal[2] | ||
Pagetoid migration including superficial third of epidermis[2] | No | No | Yes, in a maximum of 2 HPF centrally, but not peripherally | Yes, multifocal and/or in periphery | ||
Extended rete pegs | Ocassional[1] | Yes, regular[2] | Yes, varying[2] | Yes, often irregular[2] | Varying, flattened[2] | |
Concentric fibrosis | Regressive[1] | Yes[2] | Occasional[1] | |||
Lamellar fibrosis | Rarely[2] | Often[2] | Often pronounced[2] | Occasional[1] | ||
Lymphocytic infiltrate[2] | Mild, perivascular | Mild or moderate, perivascular | Varying | Varying | ||
Suprapapillary plate involvement | No[1] | Usually no[1] | Often[1] | Yes[1] | ||
Cellular (high mag.) |
Junctional extension[1] | Unusual | Usual | Extensive | ||
Nuclear size[1] | Age-related | Small | Medium | Large | Medium or large. Pleomorphic[3] | |
Nuclear pleomorphism[4] | Slight | Prominent | ||||
Chromatin pattern | Uniform[1] | Condensed[1] | Partically expanded[1] | Expanded, coarse in some cells[1] | Expanded, hyperchromatic, coarse.[1] Usually granular.[4] | |
Nucleoli[1] | Age-related | Small | Medlium | Large | Usually[4] large | |
Mitoses[1] | Few superficial | Superficial and deep | ||||
Histological regression[4][notes 2] | Usually | Usually not | ||||
Percentage of atypical melanocytes[2] | <10% | About 10 - 50% | about 50-90% | Usually> 90% | ||
Intradermal melanocytic atypia[2] | No | Rarely, in superficial part | Can be detected in superficial part | |||
Intradermal melanocyte maturation[2] | Yes | Yes, can be partial | Yes, can be partial | Variable |
In suspected but not certain nevus or melanoma in situ, generally perform immunohistochemistry with SOX10, whereby melanocyte proliferation and nuclear pleomorphism is easier to see.[notes 3]
See also
Notes
- ↑ Lentiginous proliferation is proliferation along the basal layer of the epidermis
- ↑ Histological regression is one or more areas within a tumor in which neoplastic cells have disappeared or decreased in number. In this case, this means complete or partial disappearance from areas of the dermis (and occasionally from the epidermis), which have been replaced by fibrosis, accompanied by melanophages, new blood vessels, and a variable degree of inflammation.
- Ribero, Simone; Gualano, Maria Rosaria; Osella-Abate, Simona; Scaioli, Giacomo; Bert, Fabrizio; Sanlorenzo, Martina; Balagna, Elena; Fierro, Maria Teresa; et al. (2015). "Association of Histologic Regression in Primary Melanoma With Sentinel Lymph Node Status ". JAMA Dermatology 151 (12): 1301. doi: . ISSN 2168-6068. - ↑ SOX10 stains cell nuclei of melanocytes.
- Miettinen, Markku; McCue, Peter A.; Sarlomo-Rikala, Maarit; Biernat, Wojciech; Czapiewski, Piotr; Kopczynski, Janusz; Thompson, Lester D.; Lasota, Jerzy; et al. (2015). "Sox10—A Marker for Not Only Schwannian and Melanocytic Neoplasms But Also Myoepithelial Cell Tumors of Soft Tissue ". The American Journal of Surgical Pathology 39 (6): 826–835. doi: . ISSN 0147-5185.
Main page
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 1.20 1.21 Arumi-Uria, Montserrat; McNutt, N Scott; Finnerty, Bridget (2003). "Grading of Atypia in Nevi: Correlation with Melanoma Risk ". Modern Pathology 16 (8): 764–771. doi: . ISSN 0893-3952.
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 2.17 2.18 2.19 Katarzyna Lundmark, Britta Krynitz, Ismini Vassilaki, Lena Mölne, Annika Ternesten Bratel. Histopatologisk bedömning och gradering av dysplastiskt nevus samt gränsdragning mot melanom in situ/melanom (Histopathological assessment and grading of dysplastic nevus and distinction from melanoma in situ/melanoma). KVAST (Swedish Society of Pathology). Retrieved on 2019-09-18.
- ↑ Christopher S. Hale. Skin melanocytic tumor - Melanoma - Invasive melanoma. Topic Completed: 1 May 2013. Revised: 17 September 2019
- ↑ 4.0 4.1 4.2 4.3 Husain, Ehab A; Mein, Charles; Pozo, Lucia; Blanes, Alfredo; Diaz-Cano, Salvador J (2011). "Heterogeneous topographic profiles of kinetic and cell cycle regulator microsatellites in atypical (dysplastic) melanocytic nevi ". Modern Pathology 24 (4): 471–486. doi: . ISSN 0893-3952.
Image sources