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Author: Mikael Häggström [notes 1]


Generally 10% neutral buffered formalin. Fix all thyroids at least overnight to avoid artifactual nuclear atypia.[1]

See also: General notes on fixation

Gross processing

  • Weigh[1]
  • Measure each lobe and isthmus in 3 dimensions, respectively.[1]
  • Ink outer surface,[1] at least if malignancy is suspected.[2]:[notes 2]

Serially section the specimen at 3-4mm intervals,[3] such as follows:[1]

See also: General notes on gross processing


  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
  2. Inking can be done with India ink, and will specify the serosa or resection margin in later histopathologic evaluation.
  3. 3.0 3.1 Separate coloring allows to distinguish the thyroid margin (continuous with the other lobe) from the peripheral margin (towards soft tissues).


  1. 1.0 1.1 1.2 1.3 1.4 . Gross Pathology Manual By The University of Chicago Department of Pathology. Updated 2-14-19 NAC.
  2. Monica Dahlgren, Janne Malina, Anna Måsbäck, Otto Ljungberg. Stora utskärningen. KVAST (Swedish Society of Pathology). Retrieved on 2019-09-26.
  3. . THYROID. Royal College of pathologists of Australia. Retrieved on 2019-12-17.