Difference between revisions of "Tophus"
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| − | A tophus should be sent '''dry''' to the pathology department, and '''not'' be put in formalin.<ref group=notes>Formalin dissolves the crystals.</ref> | + | A tophus specimen should be sent '''dry''' to the pathology department, and '''not''' be put in formalin.<ref group=notes>Formalin dissolves the crystals.</ref> A touch prep can be done initially, and at least if urate crystals remain suspected, the specimen is submitted in 100% alcohol for microscopy evaluation. |
| + | ==Microscopy evaluation== | ||
| + | <gallery mode=packed> | ||
| + | File:Uric acid crystals in polarized light.png|Uric acid crystals in polarized light, showing negative [[birefringence]], with yellow color when aligned parallel to the axis of the red compensator, and blue when aligned perpendicularly to it.<ref>{{cite web|url=https://emedicine.medscape.com/article/329958-workup|title=Gout and Pseudogout Workup|author=Bruce M Rothschild|website=Medscape}} Updated: Jun 30, 2020</ref> | ||
| + | </gallery> | ||
{{Bottom}} | {{Bottom}} | ||
Revision as of 15:54, 23 September 2020
Author:
Mikael Häggström [note 1]
Preparation
A tophus specimen should be sent dry to the pathology department, and not be put in formalin.[notes 1] A touch prep can be done initially, and at least if urate crystals remain suspected, the specimen is submitted in 100% alcohol for microscopy evaluation.
Microscopy evaluation
Uric acid crystals in polarized light, showing negative birefringence, with yellow color when aligned parallel to the axis of the red compensator, and blue when aligned perpendicularly to it.[1]
Notes
- ↑ Formalin dissolves the crystals.
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Bruce M Rothschild. Gout and Pseudogout Workup. Medscape. Updated: Jun 30, 2020
Image sources
