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Chronic [[appendicitis]](including peri-appendicitis):
{{Fixation - standard}}
{{Fixation - general notes}}
{{Comprehensiveness}}
==Gross processing==
{{Further|Appendix}}
A major visual clue to chronic appendicitis is fibrosis.<ref name="SierakowskiPattichis2016">{{cite journal|last1=Sierakowski|first1=Kyra|last2=Pattichis|first2=Andrew|last3=Russell|first3=Patrick|last4=Wattchow|first4=David|title=Unusual presentation of a familiar pathology: chronic appendicitis|journal=BMJ Case Reports|year=2016|pages=bcr2015212485|issn=1757-790X|doi=10.1136/bcr-2015-212485}}</ref> {{Moderate-begin}}When the referral and/or history suggests chronic appendicitis, take additional slices for microscopy.{{Moderate-end}}<ref group=notes>It will require additional slices to comfortably rule out acute appendicitis.</ref>
==Microscopic evaluation==
Chronic appendicitis has predominantly ''mononuclear'' infiltrate rather than neutrophilic.<ref name="SierakowskiPattichis2016"/> It must go beyond the normal histological locations of mononuclear leucocytes of the appendix.
Even when chronic appendicitis is detected, also look for acute appendicitis, as well as appendix cancer .({{further|Appendix|linebreak=no}})
===Microscopy report===
{{Moderate-begin}}Note even the absence of acute appendicitis.{{Moderate-end}}
Example:
{|class="wikitable"
| [[File:Histopathology of patchy chronic peri-appendicitis.jpg|100px|left]] Patchy chronic peri-appendicitis. {{Moderate-begin}}Negative for suppurative acute inflammation.{{Moderate-end}}
|}
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