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{{Fixation - standard}}
Fresh breast specimens should be put in formalin within one hour.<ref group=notes name=time>An increased cold ischemia time (time from procurement to time in formalin) negatively effects the utility of immunohistochemistry.<br>- {{cite journal|last1=Khoury|first1=Thaer|title=Delay to Formalin Fixation (Cold Ischemia Time) Effect on Breast Cancer Molecules|journal=American Journal of Clinical Pathology|volume=149|issue=4|year=2018|pages=275–292|issn=0002-9173|doi=10.1093/ajcp/aqx164}}</ref> Breast specimens should be immersed in formalin for 6-72 hours.<ref>{{cite web|url=https://webapps.cap.org/apps/docs/committees/immunohistochemistry/her2_faqs.pdf|title=Recommendations for HER2 Testing in Breast Cancer: ASCO – CAP Clinical Practice Guideline Update|date=2013-10-17|website=College of American Pathologists}}</ref>
{{Comprehensiveness|otherlegend=yes}}
:*Consistency<ref name=Roychowdhury/>
*{{Moderate-begin}}Description of sectioning and submissions.{{Moderate-end}}
*{{Comprehensive-begin}}Time of procurement and time of placement in formalin, in order to be able to calculate the cold ischemia time, which has effects on immunohistochemistry.<ref group=notes name="Khoury2018">{{cite journal|last1=Khoury|first1=Thaer|title=Delay to Formalin Fixation (Cold Ischemia Time) Effect on Breast Cancer Molecules|journal=American Journal of Clinical Pathology|volume=149|issue=4|year=2018|pages=275–292|issn=0002-9173|doi=10.1093time/ajcp/aqx164}}</ref>{{Comprehensive-end}}
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