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→Gross processing: Expanded
*Determine total specimen '''size'''. {{Comprehensive-begin}}Weight the specimen<ref name=Roychowdhury>{{cite web|url=https://www.pathologyoutlines.com/topic/breastmalignantgrossing.html|title=Grossing (histologic sampling) of breast lesions|author=Monika Roychowdhury|website=Pathologyoutlines.com}} Topic Completed: 1 August 2012. Revised: 19 September 2019</ref>{{Comprehensive-end}}
*'''[[Ink]]''' margins. If sample orientations are marked, use different colors for different directions.<ref name=Roychowdhury/>
*'''Palpate''' the specimen for masses. Compare with radiograph radiography if available.<ref name=Roychowdhury/>Confirm the presence of any known biopsy clips, either visibly or by post-operative radiography (in order to confirm that the specimen includes the region of interest).*Make '''Serially section''' the specimen.:*When performing '''triage''' of fresh lumpectomies, make slices about 1.5 cm thick. When laid down and flattened, this is generally thin enough to allow for fixation overnight.:*When selecting tissue for submission, make 3-4 mm thick '''slices'''.<ref name=Roychowdhury/>
*Submit:<ref name=Roychowdhury/>
:*Entire specimen if it can fit in 3-5 slices.
:*If larger, 1 slice per cm of tumor (minimum of 3 slices of tumor), including both center and periphery of tumor.
:*Additional suspicious areas, including those indicated by mammographyradiography
Breast specimens where breast cancer are possible should generally not be decalcified even when containing small calcifications, to preserve the ability to perform immunohistochemistry.
{{Gross processing}}
