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→Gross processing: +Margins
:*When selecting tissue for submission after fixation, make 3-4 mm thick '''slices'''.<ref name=Roychowdhury/>
*'''Inspect''' for any grossly visible lesions. If found, measure at least the greatest dimension of the lesion on the slice where it appears largest. {{Moderate-begin}}Also compare the greatest gross measurement (including any palpated one) with the greatest measurement at previous imaging, and note if it confers a staging discrepancy between imaging and gross dimensions, with cutoffs at 0.1 cm, 0.5 cm, 1.0 cm, 2.0 cm, and 5 cm.{{Moderate-end}}
===Tissue selection===*'''Submit''':<ref name=Roychowdhury/>
:*Entire specimen if it can fit in 3-5 slices.
:*If larger, 1 slice per cm of tumor (minimum of 3 slices of tumor), including both center and periphery of tumor, including closest distance to the surgical margin if possible.
:*Additional suspicious areas, including those indicated by radiography.
:*{{Comprehensive-begin}}Representative sections of margins in each direction.{{Comprehensive-end}}
Breast specimens where breast cancer is possible should generally not be decalcified even when containing small calcifications, to preserve the ability to perform immunohistochemistry.
{{Gross processing}}
