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Within an hour after removal from the body,<ref>{{cite web|url=https://www.uclahealth.org/pathology/workfiles/Education/Residency%20Program/Gross%20Manual/Mastectomy%2006.03.20.pdf|title=Breast pathology grossing guidelines|website=UCLA Health|accessdate=2021-09-09}}</ref> tissue samples should generally be placed in vessels with the correct fixing solution, with a volume that allows them to lie freely in the solution.<ref name=kvast>{{cite web|url=http://www.svfp.se/foreningar/uploads/L15178/kvast/hud/Handlaggning%20av%20hudprover%20%20provtagningsanvisningar%20utskarningsprinciper%20och%20snittning%2020150325.pdf|title=Handläggning av hudprover – provtagningsanvisningar, utskärningsprinciper och snittning (Handling of skin samples - Instructions for sampling, cutting and incision|author=Katarzyna Lundmark, Krynitz, Ismini Vassilaki, Lena Mölne, Annika Ternesten Bratel|accessdate=2019-09-09|website=KVAST (Swedish Society of Pathology)}}</ref> The standard fixation fluid is generally 10% neutral buffered '''formalin''', which is roughly equivalent to 4% formaldehyde.<ref>{{cite web|url=https://microscopy.duke.edu/guides/paraformaldehyde-formaldehyde-formalin|title=Paraformaldehyde, Formadehyde and Formalin|website=Duke University|accessdate=2019-12-17}}</ref>
The main exception to using formalin are mainly:
*A '''[[tophus]]''' or other specimen suspicious for gout versus pseudogout should be sent in alcohol or dry, since formalin will dissolve the crystals.
*[[Lymph node]]s (or other lymphoid aggregates) with a suspicion of '''lymphoma''', where samples are generally put in a special solution for flow cytometry.*[[Products of conception]] with a need to take samples for '''genetic testing'''.
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