* 3 points: nuclei with marked variation in size and shape
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File:Micrograph of ductal carcinoma with mild nuclear pleomorphism.jpg|Ductal carcinoma with mild nuclear pleomorphism.File:Micrograph Histopathology of invasive ductal lobular carcinoma of tubular type with moderate nuclear pleomorphism (crop).jpg|Invasive ductal lobular carcinoma with '''moderate nuclear pleomorphism. File:Micrograph of invasive ductal carcinoma with marked nuclear pleomorphism.jpg|thumb|Invasive ductal carcinoma with marked ''' nuclear pleomorphism.
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