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Endometrial cancer

1,101 bytes added, 19:53, 24 September 2021
File:Histopathology of solid FIGO grade 3 endometrioid carcinoma of the endometrium.png|3 endometrioid carcinoma|'''Grade 3''', with solid architecture.<ref name=Murali2019>{{cite journal| author=Rajmohan Murali, M.B.B.S., M.D., F.R.C.P.A., Ben Davidson, M.D., Ph.D., Oluwole Fadare, M.D., Joseph A. Carlson, M.D., Ph.D., Christopher P. Crum, M.D., C. Blake Gilks, M.D., Julie A. Irving, M.D., F.R.C.P.C., Anais Malpica, M.D., Xavier Matias-Guiu, M.D., Ph.D., W. Glenn McCluggage, F.R.C.Path., Khush Mittal, M.D., Esther Oliva, M.D., Vinita Parkash, M.D., Joanne K. L. Rutgers, M.D., Paul N. Staats, M.D., Colin J. R. Stewart, M.D., Carmen Tornos, M.D., and Robert A. Soslow, M.D. | title=High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations. | journal=Int J Gynecol Pathol | year= 2019 | volume= 38 Suppl 1 | issue= | pages= S40-S63 | pmid=30550483 | doi=10.1097/PGP.0000000000000491 | pmc=6296248 | url= }}<br>- "This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."</ref> Carcinomas with identifiable endometrial component, and with over 50% solid architecture should be classified as grade 3 endometrioid carcinoma.<ref name=Murali2019/>
:{{Comprehensive-begin}}Also perform '''nuclear grading:'''{{Comprehensive-end}}
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File:Histopathology of endometrioid cancer, grade 1, nuclear grade 1.jpg|'''Nuclear grade 1''': Oval, mildly enlarged nucleus with evenly distributed chromatin.{{MH}}<ref name="pmid22496699">{{cite journal| author=Nofech-Mozes S, Ismiil N, Dubé V, Saad RS, Ghorab Z, Grin A | display-authors=etal| title=Interobserver agreement for endometrial cancer characteristics evaluated on biopsy material. | journal=Obstet Gynecol Int | year= 2012 | volume= 2012 | issue= | pages= 414086 | pmid=22496699 | doi=10.1155/2012/414086 | pmc=3306930 | url= }} </ref>
File:Histopathology of endometrioid cancer, grade 1, nuclear grade 2.jpg|'''Nuclear grade 2''': Intermediate features.{{MH}}<ref name="pmid22496699"/>
*'''Nuclear grade 3''': Markedly enlarged and pleomorphic nuclei, with coarse chromatin and distinct nucleoli.<ref name="pmid22496699"/>

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