Template:Mitotic count in invasive breast cancer

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Author:

Mikael Häggström [note 1]

Mitosis appearances in breast cancer

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Mitotic figures are counted only at the periphery of the tumor, and counting should begin in the most mitotically active areas, and in at least 10 high-power fields (HPFs). If you know that the area of your high power field is about 0.2mm2, then you may score mitotic count as follows:[1]

  • 1 point: ≤7 mitoses per 10 HPFs
  • 2 points: 8 to 14 mitoses per 10 HPFs
  • 3 points: ≥15 mitoses per 10 HPFs

If you have a significant different HPF area or you are not sure, count 10 HPFs and calculate the number of mitoses per mm2 (Further information: Evaluation#Counts per mm2 ):

  • 1 point: ≤3 mitoses per mm2
  • 2 points: 4 to 7 mitoses per mm2
  • 3 points: ≥7 mitoses per mm2

A table of counts for various HPF sizes is available at the College of American Pathologists. [1] (Page 22)

Notes

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References

  1. Error on call to Template:cite web: Parameters url and title must be specified. . College of American Pathologists. Protocol Posting Date: September 2022

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