Urothelial versus squamous-cell carcinoma
(Redirected from Urothelial versus squamous cell carcinoma)
Author:
Mikael Häggström [note 1]
Gross processing
- As per urinary bladder
Microscopic examination
- Urothelial carcinoma with squamous differentiation will have some urothelial carcinoma areas and some areas looking like squamous cell carcinoma of the skin.
- Squamous cell carcinoma of the urinary bladder should not have areas appearing like urothelial carcinoma.
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Urothelial carcinoma with squamous differentiation. -
Squamous cell carcinoma of the urinary bladder.
In uncertain cases, perform immunohistochemistry for S100P and GATA3, where positivity indicates urothelial carcinomas with squamous differentiation (positive in 83% and 35% respectively), and negativity indicates squamous cell carcinomas (positive in 9% and near-0%, respectively).[1]
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Gulmann, Christian; Paner, Gladell P.; Parakh, Rugvedita S.; Hansel, Donna E.; Shen, Steven S.; Ro, Jae Y.; Annaiah, Chandrakanth; Lopez-Beltran, Antonio; et al. (2013). "Immunohistochemical profile to distinguish urothelial from squamous differentiation in carcinomas of urothelial tract ". Human Pathology 44 (2): 164–172. doi:. ISSN 00468177.
Image sources