Junctional nevus - Revision history

Mikael Häggström: /* Report */ Expanded

2023-10-24T16:43:49Z

Report: Expanded

← Older revision		Revision as of 12:43, 24 October 2023
Line 26:		Line 26:

	===Report===		===Report===
	*~~Size~~		*Presence or absence of atypia.
	*Preferably findings included in table.		:{{Moderate-begin}}If atypical, low-or high grade, or degree of atypia.{{Moderate-end}}
	*{{Comprehensive-begin}}Most likely grade if possible.{{Comprehensive-end}}		*{{Comprehensive-begin}}Size
			*Findings included in table above if applicable.
			*Most likely grade if possible.{{Comprehensive-end}}
			{\|class=wikitable
			\| Skin, upper back, excision:<br>- Junctional {{Moderate-begin}}melanocytic{{Moderate-end}} nevus with {{Moderate-begin}}moderate{{Moderate-end}} atypia.
			\|}
	{{Reporting}}		{{Reporting}}
	{{Bottom}}		{{Bottom}}

Mikael Häggström: Sized

2020-10-05T13:04:43Z

Sized

← Older revision		Revision as of 09:04, 5 October 2020
Line 3:		Line 3:
	\|author2=		\|author2=
	}}		}}
	[[File:Histopathology of melanocytic nevus 2.jpg\|thumb\|'''Junctional nevus''' (here seen in H&E stain and Melan A stain), where all nests are continuous with the epidermis.]]		[[File:Histopathology of melanocytic nevus 2.jpg\|thumb\|350px\|'''Junctional nevus''' (here seen in H&E stain and Melan A stain), where all nests are continuous with the epidermis.]]
	{{Comprehensiveness}}		{{Comprehensiveness}}
	A suspected dysplastic nevus (also called dysplastic melanocytic nevus) generally presents as a [[Dark skin focalities\|dark skin focality]].		A suspected dysplastic nevus (also called dysplastic melanocytic nevus) generally presents as a [[Dark skin focalities\|dark skin focality]].

Mikael Häggström: +Image

2020-10-05T13:02:26Z

+Image

← Older revision		Revision as of 09:02, 5 October 2020
Line 3:		Line 3:
	\|author2=		\|author2=
	}}		}}
			[[File:Histopathology of melanocytic nevus 2.jpg\|thumb\|'''Junctional nevus''' (here seen in H&E stain and Melan A stain), where all nests are continuous with the epidermis.]]
	{{Comprehensiveness}}		{{Comprehensiveness}}
	A suspected dysplastic nevus (also called dysplastic melanocytic nevus) generally presents as a [[Dark skin focalities\|dark skin focality]].		A suspected dysplastic nevus (also called dysplastic melanocytic nevus) generally presents as a [[Dark skin focalities\|dark skin focality]].

Mikael Häggström: Comprehensiveness

2020-10-05T12:39:29Z

Comprehensiveness

← Older revision		Revision as of 08:39, 5 October 2020
Line 3:		Line 3:
	\|author2=		\|author2=
	}}		}}
			{{Comprehensiveness}}
	A suspected dysplastic nevus (also called dysplastic melanocytic nevus) generally presents as a [[Dark skin focalities\|dark skin focality]].		A suspected dysplastic nevus (also called dysplastic melanocytic nevus) generally presents as a [[Dark skin focalities\|dark skin focality]].
	{{Fixation - standard}}		{{Fixation - standard}}
Line 26:		Line 27:
	*Size		*Size
	*Preferably findings included in table.		*Preferably findings included in table.
	*Most likely grade if possible.		*{{Comprehensive-begin}}Most likely grade if possible.{{Comprehensive-end}}
	{{Reporting}}		{{Reporting}}
	{{Bottom}}		{{Bottom}}

Mikael Häggström: /* Differential diagnosis */ Formatting

2020-10-05T12:32:27Z

Differential diagnosis: Formatting

← Older revision		Revision as of 08:32, 5 October 2020
Line 15:		Line 15:
	File:Histopathology of lentigo maligna.jpg\|'''[[Melanoma in situ]]''', by higher atypia and dysplasia (see table in [[#Grading\|the grading section]]).		File:Histopathology of lentigo maligna.jpg\|'''[[Melanoma in situ]]''', by higher atypia and dysplasia (see table in [[#Grading\|the grading section]]).
	File:Histopathology of dermal nevus, high magnification.jpg\|'''[[Dermal nevus]]''', with nevus cells enclosed within the dermis.		File:Histopathology of dermal nevus, high magnification.jpg\|'''[[Dermal nevus]]''', with nevus cells enclosed within the dermis.
	File:Histopathology of compound nevus.jpg\|thumb\|'''Compound nevus''', with cells in both dermis and epidermis.]]		File:Histopathology of compound nevus.jpg\|thumb\|'''Compound nevus''', with nevus cells in both dermis and epidermis.
	</gallery>		</gallery>
	*'''[[Epidermal nevus]]''', nests of nevus cells enclosed within the epidermis.		*'''[[Epidermal nevus]]''', nests of nevus cells enclosed within the epidermis.

Mikael Häggström: /* Differential diagnosis */ +Compound

2020-10-05T12:31:55Z

Differential diagnosis: +Compound

← Older revision		Revision as of 08:31, 5 October 2020
Line 15:		Line 15:
	File:Histopathology of lentigo maligna.jpg\|'''[[Melanoma in situ]]''', by higher atypia and dysplasia (see table in [[#Grading\|the grading section]]).		File:Histopathology of lentigo maligna.jpg\|'''[[Melanoma in situ]]''', by higher atypia and dysplasia (see table in [[#Grading\|the grading section]]).
	File:Histopathology of dermal nevus, high magnification.jpg\|'''[[Dermal nevus]]''', with nevus cells enclosed within the dermis.		File:Histopathology of dermal nevus, high magnification.jpg\|'''[[Dermal nevus]]''', with nevus cells enclosed within the dermis.
			File:Histopathology of compound nevus.jpg\|thumb\|'''Compound nevus''', with cells in both dermis and epidermis.]]
	</gallery>		</gallery>
	*'''[[Epidermal nevus]]''', nests of nevus cells enclosed within the epidermis.		*'''[[Epidermal nevus]]''', nests of nevus cells enclosed within the epidermis.

Mikael Häggström: /* Differential diagnosis */ Expanded

2020-03-16T13:49:02Z

Differential diagnosis: Expanded

← Older revision		Revision as of 09:49, 16 March 2020
Line 14:		Line 14:
	<gallery mode=packed heights=200>		<gallery mode=packed heights=200>
	File:Histopathology of lentigo maligna.jpg\|'''[[Melanoma in situ]]''', by higher atypia and dysplasia (see table in [[#Grading\|the grading section]]).		File:Histopathology of lentigo maligna.jpg\|'''[[Melanoma in situ]]''', by higher atypia and dysplasia (see table in [[#Grading\|the grading section]]).
			File:Histopathology of dermal nevus, high magnification.jpg\|'''[[Dermal nevus]]''', with nevus cells enclosed within the dermis.
	</gallery>		</gallery>
			*'''[[Epidermal nevus]]''', nests of nevus cells enclosed within the epidermis.

	===Grading===		===Grading===

Mikael Häggström: +Fixation

2020-03-16T13:31:41Z

+Fixation

← Older revision		Revision as of 09:31, 16 March 2020
Line 4:		Line 4:
	}}		}}
	A suspected dysplastic nevus (also called dysplastic melanocytic nevus) generally presents as a [[Dark skin focalities\|dark skin focality]].		A suspected dysplastic nevus (also called dysplastic melanocytic nevus) generally presents as a [[Dark skin focalities\|dark skin focality]].
			{{Fixation - standard}}
	{{Gross processing of skin excisions}}		{{Gross processing of skin excisions}}
	==Microscopic evaluation==		==Microscopic evaluation==

Mikael Häggström: /* Grading */ Templated

2020-03-16T13:30:14Z

Grading: Templated

← Older revision		Revision as of 09:30, 16 March 2020
Line 16:		Line 16:

	===Grading===		===Grading===
	~~It is acceptable to grade a dysplastic nevus into either low or high grade by the following algorithm:<ref>~~{{cite journal\|last1=Pozo\|first1=Lucia\|last2=Naase\|first2=Mahmoud\|last3=Cerio\|first3=Rino\|last4=Blanes\|first4=Alfredo\|last5=Diaz-Cano\|first5=Salvador J.\|title=Critical Analysis of Histologic Criteria for Grading Atypical (Dysplastic) Melanocytic Nevi\|journal=American Journal of Clinical Pathology\|volume=115\|issue=2\|year=2001\|pages=194–204\|issn=0002-9173\|doi=10.1309/KXJW-1UJE-BPG6-AXBV}}</ref><ref group="notes" name="regression"/>		{{Epidermal and junctional nevus grading}}
	~~[[File:Algorithm for low grade versus high grade dysplastic~~ nevus~~.png\|center\|250px]]~~

	~~In uncertain cases, more specific~~ grading~~, and/or differentiation from a non-atypical congenital nevus and suspected [[melanoma]], the following table can be used to determine the most fitting diagnosis:~~

	~~{{Table comparing congenital nevus, dysplastic nevus and suspected melanoma~~}}
	[[File:SOX10 immunohistochemistry of normal skin (edited).jpg\|thumb\|center\|300px\|In contrast, normal skin (pictured) has a melanocyte about every 4 cells along the basement membrane.]]		[[File:SOX10 immunohistochemistry of normal skin (edited).jpg\|thumb\|center\|300px\|In contrast, normal skin (pictured) has a melanocyte about every 4 cells along the basement membrane.]]

Mikael Häggström: /* Microscopic evaluation */ Updated

2020-03-11T11:41:27Z

Microscopic evaluation: Updated

← Older revision		Revision as of 07:41, 11 March 2020
Line 6:		Line 6:
	{{Gross processing of skin excisions}}		{{Gross processing of skin excisions}}
	==Microscopic evaluation==		==Microscopic evaluation==
	~~''Mandatory findings''~~:<ref ~~name~~=~~KVAST~~/>		A junctional nevus is characterized by:<ref>{{cite web\|url=https://www.pathologyoutlines.com/topic/skintumormelanocyticJunctnevus.html\|title=Skin melanocytic tumor - Nevi - Junctional nevus\|author=Christopher S. Hale, M.D.\|website=Pathology Outlines}} Topic Completed: 1 February 2017. Revised: 4 April 2019</ref>
	*Shoulder phenomenon, ~~meaning that the extent of the dermal component is larger than the epidermal component~~.		*Rounded melanocyte nests on the epidermal side of dermoepidermal junction
	*Lentiginous proliferation, meaning an increased amount of melanocytes in the basal area, along rete pegs and sometimes between them.		*Variable lentiginous melanocytic hyperplasia
	*~~Irregularly distributed~~ nests of ~~melanocytes.~~
	*~~Atypia~~

	===Differential diagnosis===		===Differential diagnosis===