Mikael Häggström: Cleanup

2024-01-11T19:56:24Z

Cleanup

← Older revision		Revision as of 15:56, 11 January 2024
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	==Microscopic evaluation==		==Microscopic evaluation==
	[[File:Histopathology of meningioma.png\|thumb\|Histopathology of a typical WHO grade 1 meningioma, [[H&E stain]]. It is of the meningothelial histologic type, which is the most common meningioma type. It shows its typical findings:<br>- A woven architectural pattern<br>- Psammoma bodies (spheroid calcifications)<br>- Syncytial cells (having indistinct cell membranes) with eosinophilic (pink) cytoplasms<br>- Round uniform nuclei<br>- Whorls (concentric cell arrangements)<ref>Image by Mikael Häggström, MD. Reference for typical findings: {{cite web\|url=https://www.pathologyoutlines.com/topic/cnstumormeningiomageneral.html\|title=Meningioma\|website=Pathology Outlines\|author=Chunyu Cai, M.D., Ph.D.}} Last author update: 10 November 2021}}</ref>]]		[[File:Histopathology of meningioma.png\|thumb\|Histopathology of a typical WHO grade 1 meningioma, H&E stain. It is of the meningothelial histologic type, which is the most common meningioma type. It shows its typical findings:<br>- A woven architectural pattern<br>- Psammoma bodies (spheroid calcifications)<br>- Syncytial cells (having indistinct cell membranes) with eosinophilic (pink) cytoplasms<br>- Round uniform nuclei<br>- Whorls (concentric cell arrangements)<ref>Image by Mikael Häggström, MD. Reference for typical findings: {{cite web\|url=https://www.pathologyoutlines.com/topic/cnstumormeningiomageneral.html\|title=Meningioma\|website=Pathology Outlines\|author=Chunyu Cai, M.D., Ph.D.}} Last author update: 10 November 2021}}</ref>]]
	Look for the signs of both typical meningioma and main histological variants. On frozen sections, mention the presence of atypia/high-grade cells.		Look for the signs of both typical meningioma and main histological variants. On frozen sections, mention the presence of atypia/high-grade cells.
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Mikael Häggström: Expanded

2024-01-11T19:55:32Z

Expanded

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==Gross processing==
{{further|Brain/meningeal tumor}}
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==Microscopic evaluation==
[[File:Histopathology of meningioma.png|thumb|Histopathology of a typical WHO grade 1 meningioma, [[H&E stain]]. It is of the meningothelial histologic type, which is the most common meningioma type. It shows its typical findings: - A woven architectural pattern - Psammoma bodies (spheroid calcifications) - Syncytial cells (having indistinct cell membranes) with eosinophilic (pink) cytoplasms - Round uniform nuclei - Whorls (concentric cell arrangements)<ref>Image by Mikael Häggström, MD. Reference for typical findings: {{cite web|url=https://www.pathologyoutlines.com/topic/cnstumormeningiomageneral.html|title=Meningioma|website=Pathology Outlines|author=Chunyu Cai, M.D., Ph.D.}} Last author update: 10 November 2021}}</ref>]]
Look for the signs of both typical meningioma and main histological variants. On frozen sections, mention the presence of atypia/high-grade cells.
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File:Histologic variants of meningioma.png|Histologic variants of meningioma, H&E stain<ref>{{cite journal| author=Brabec J, Friedjungová M, Vašata D, Englund E, Bengzon J, Knutsson L | display-authors=etal| title=Meningioma microstructure assessed by diffusion MRI: An investigation of the source of mean diffusivity and fractional anisotropy by quantitative histology. | journal=Neuroimage Clin | year= 2023 | volume= 37 | issue= | pages= 103365 | pmid=36898293 | doi=10.1016/j.nicl.2023.103365 | pmc=10020119 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=36898293 }} - "This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)"</ref>
File:Low-grade and high-grade meningioma.png|thumb|Meningioma, low-grade and high-grade. H&E stain.<ref>{{cite journal| author=Wu C, Zhong J, Lin L, Chen Y, Xue Y, Shi P| title=Segmentation of HE-stained meningioma pathological images based on pseudo-labels. | journal=PLoS One | year= 2022 | volume= 17 | issue= 2 | pages= e0263006 | pmid=35120175 | doi=10.1371/journal.pone.0263006 | pmc=8815980 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=35120175 }} - Creative Commons Attribution 4.0 International license</ref>
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On permanent sections, classify by WHO grade:
{| class="wikitable"
|+ Meningioma grades<ref>{{cite web|url=https://www.aans.org/en/Patients/Neurosurgical-Conditions-and-Treatments/Meningiomas|title=Meningiomas|website=American Association of Neurological Surgeons|author= Jeffrey I. Traylor, MD and John S. Kuo, MD, PhD, FAANS.|accessdate=2024-01-11}}</ref>
|-
! WHO Grade I
! WHO Grade II
! WHO Grade III
|-
| Benign
| Atypical
| Malignant
|-
|
*Meningiothelial
*Fibrous (fibroblastic)
*Transitional (mixed)
*Psammomatous
*Angiomatous
*Microcystic
*Secretory
*Lymphoplasmacyte-rich
*Metaplastic
|
*Chordoid
*Clear Cell
*Atypical
|
*Papillary
*Rhabdoid
*Anaplastic
|}

==Reporting==
Example frozen section report:
{|class=wikitable
| A. Right frontal tumor: -Meningioma. Negative for atypia.
|}

Example permanent section report:
{|class=wikitable
| A. Right frontal tumor: -Meningioma, WHO grade 1.
|}
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Meningioma - Revision history

Mikael Häggström: Cleanup

Mikael Häggström: Expanded