Pituitary - Revision history

Mikael Häggström: /* Microscopic evaluation */ packed

2021-02-11T13:38:04Z

Microscopic evaluation: packed

← Older revision		Revision as of 09:38, 11 February 2021
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	*If present, distinguish it as '''hyperplasia or neoplasia'''. If uncertain, by using reticulin immunohistochemistry, hyperplasia will show a preserved reticulin meshwork, whereas pituitary adenomas have disruption of it.<ref name="Al-BrahimAsa2006">{{cite journal\|last1=Al-Brahim\|first1=N Y Y\|last2=Asa\|first2=S L\|title=My approach to pathology of the pituitary gland\|journal=Journal of Clinical Pathology\|volume=59\|issue=12\|year=2006\|pages=1245–1253\|issn=0021-9746\|doi=10.1136/jcp.2005.031187}}</ref>		*If present, distinguish it as '''hyperplasia or neoplasia'''. If uncertain, by using reticulin immunohistochemistry, hyperplasia will show a preserved reticulin meshwork, whereas pituitary adenomas have disruption of it.<ref name="Al-BrahimAsa2006">{{cite journal\|last1=Al-Brahim\|first1=N Y Y\|last2=Asa\|first2=S L\|title=My approach to pathology of the pituitary gland\|journal=Journal of Clinical Pathology\|volume=59\|issue=12\|year=2006\|pages=1245–1253\|issn=0021-9746\|doi=10.1136/jcp.2005.031187}}</ref>
	:*For '''adenomas''', unless otherwise indicated by the medical history, will generally by definition be of the silent type. Basophilic or acidophilic staining may give a clue about the subtype, but immunohistochemistry is generally required.		:*For '''adenomas''', unless otherwise indicated by the medical history, will generally by definition be of the silent type. Basophilic or acidophilic staining may give a clue about the subtype, but immunohistochemistry is generally required.
	<gallery>		<gallery mode=packed heights=190>
	File:Histology of pars distalis of the anterior pituitary with chromophobes, basophils, and acidophils, annotated.jpg\|'''Normal''' cellular heterogeneity of the anterior pituitary. Nuclear pleomorphism, like the large nucleus of the chromophobe, is a normal finding in this location.		File:Histology of pars distalis of the anterior pituitary with chromophobes, basophils, and acidophils, annotated.jpg\|'''Normal''' cellular heterogeneity of the anterior pituitary. Nuclear pleomorphism, like the large nucleus of the chromophobe, is a normal finding in this location.
	File:Pie chart of incidences of silent pituitary adenomas.png\|Incidences of silent pituitary adenomas.<ref>{{cite journal\|last1=Drummond\|first1=Juliana\|last2=Roncaroli\|first2=Federico\|last3=Grossman\|first3=Ashley B\|last4=Korbonits\|first4=Márta\|title=Clinical and Pathological Aspects of Silent Pituitary Adenomas\|journal=The Journal of Clinical Endocrinology & Metabolism\|volume=104\|issue=7\|year=2019\|pages=2473–2489\|issn=0021-972X\|doi=10.1210/jc.2018-00688}}<br>- "This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/)"</ref>		File:Pie chart of incidences of silent pituitary adenomas.png\|Incidences of silent pituitary adenomas.<ref>{{cite journal\|last1=Drummond\|first1=Juliana\|last2=Roncaroli\|first2=Federico\|last3=Grossman\|first3=Ashley B\|last4=Korbonits\|first4=Márta\|title=Clinical and Pathological Aspects of Silent Pituitary Adenomas\|journal=The Journal of Clinical Endocrinology & Metabolism\|volume=104\|issue=7\|year=2019\|pages=2473–2489\|issn=0021-972X\|doi=10.1210/jc.2018-00688}}<br>- "This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/)"</ref>

Mikael Häggström: /* Microscopic evaluation */ +Normal

2021-02-11T13:37:44Z

Microscopic evaluation: +Normal

← Older revision		Revision as of 09:37, 11 February 2021
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	==Microscopic evaluation==		==Microscopic evaluation==
	*Look for '''cellular expansions'''		*Look for '''cellular expansions''', which in the anterior pituitary confers a loss of normal cellular heterogeneity.
	*If present, distinguish it as '''hyperplasia or neoplasia'''. If uncertain, by using reticulin immunohistochemistry, hyperplasia will show a preserved reticulin meshwork, whereas pituitary adenomas have disruption of it.<ref name="Al-BrahimAsa2006">{{cite journal\|last1=Al-Brahim\|first1=N Y Y\|last2=Asa\|first2=S L\|title=My approach to pathology of the pituitary gland\|journal=Journal of Clinical Pathology\|volume=59\|issue=12\|year=2006\|pages=1245–1253\|issn=0021-9746\|doi=10.1136/jcp.2005.031187}}</ref>		*If present, distinguish it as '''hyperplasia or neoplasia'''. If uncertain, by using reticulin immunohistochemistry, hyperplasia will show a preserved reticulin meshwork, whereas pituitary adenomas have disruption of it.<ref name="Al-BrahimAsa2006">{{cite journal\|last1=Al-Brahim\|first1=N Y Y\|last2=Asa\|first2=S L\|title=My approach to pathology of the pituitary gland\|journal=Journal of Clinical Pathology\|volume=59\|issue=12\|year=2006\|pages=1245–1253\|issn=0021-9746\|doi=10.1136/jcp.2005.031187}}</ref>
	:*For '''adenomas''', unless otherwise indicated by the medical history, will generally by definition be of the silent type. Basophilic or acidophilic staining may give a clue about the subtype, but immunohistochemistry is generally required.		:*For '''adenomas''', unless otherwise indicated by the medical history, will generally by definition be of the silent type. Basophilic or acidophilic staining may give a clue about the subtype, but immunohistochemistry is generally required.
	<gallery>		<gallery>
			File:Histology of pars distalis of the anterior pituitary with chromophobes, basophils, and acidophils, annotated.jpg\|'''Normal''' cellular heterogeneity of the anterior pituitary. Nuclear pleomorphism, like the large nucleus of the chromophobe, is a normal finding in this location.
	File:Pie chart of incidences of silent pituitary adenomas.png\|Incidences of silent pituitary adenomas.<ref>{{cite journal\|last1=Drummond\|first1=Juliana\|last2=Roncaroli\|first2=Federico\|last3=Grossman\|first3=Ashley B\|last4=Korbonits\|first4=Márta\|title=Clinical and Pathological Aspects of Silent Pituitary Adenomas\|journal=The Journal of Clinical Endocrinology & Metabolism\|volume=104\|issue=7\|year=2019\|pages=2473–2489\|issn=0021-972X\|doi=10.1210/jc.2018-00688}}<br>- "This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/)"</ref>		File:Pie chart of incidences of silent pituitary adenomas.png\|Incidences of silent pituitary adenomas.<ref>{{cite journal\|last1=Drummond\|first1=Juliana\|last2=Roncaroli\|first2=Federico\|last3=Grossman\|first3=Ashley B\|last4=Korbonits\|first4=Márta\|title=Clinical and Pathological Aspects of Silent Pituitary Adenomas\|journal=The Journal of Clinical Endocrinology & Metabolism\|volume=104\|issue=7\|year=2019\|pages=2473–2489\|issn=0021-972X\|doi=10.1210/jc.2018-00688}}<br>- "This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/)"</ref>
	File:Histopathology of eosinophilic silent gonadotroph pituitary adenoma.jpg\|A silent gonadotroph pituitary adenoma which is in this case is eosinophilic (contrary to normal, basophilic, gonadotroph cells).<ref>{{cite journal\|last1=Gaballa\|first1=Salem\|last2=Lindsay\|first2=Jane\|last3=AlJaf\|first3=Avan\|last4=Hlaing\|first4=Kyaw M\|last5=Patel\|first5=Kashyap\|title=Acute Unilateral Oculomotor Nerve Palsy as the Initial Presenting Sign of Nonfunctioning Apoplectic Gonadotroph Adenoma\|journal=Cureus\|year=2020\|issn=2168-8184\|doi=10.7759/cureus.8819}}<br>- "This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0"</ref>		File:Histopathology of eosinophilic silent gonadotroph pituitary adenoma.jpg\|A silent gonadotroph pituitary '''adenoma''' which is in this case is eosinophilic (contrary to normal, basophilic, gonadotroph cells).<ref>{{cite journal\|last1=Gaballa\|first1=Salem\|last2=Lindsay\|first2=Jane\|last3=AlJaf\|first3=Avan\|last4=Hlaing\|first4=Kyaw M\|last5=Patel\|first5=Kashyap\|title=Acute Unilateral Oculomotor Nerve Palsy as the Initial Presenting Sign of Nonfunctioning Apoplectic Gonadotroph Adenoma\|journal=Cureus\|year=2020\|issn=2168-8184\|doi=10.7759/cureus.8819}}<br>- "This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0"</ref>
	</gallery>		</gallery>

Mikael Häggström: +Report

2020-11-18T19:10:00Z

+Report

← Older revision		Revision as of 15:10, 18 November 2020
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	File:Histopathology of eosinophilic silent gonadotroph pituitary adenoma.jpg\|A silent gonadotroph pituitary adenoma which is in this case is eosinophilic (contrary to normal, basophilic, gonadotroph cells).<ref>{{cite journal\|last1=Gaballa\|first1=Salem\|last2=Lindsay\|first2=Jane\|last3=AlJaf\|first3=Avan\|last4=Hlaing\|first4=Kyaw M\|last5=Patel\|first5=Kashyap\|title=Acute Unilateral Oculomotor Nerve Palsy as the Initial Presenting Sign of Nonfunctioning Apoplectic Gonadotroph Adenoma\|journal=Cureus\|year=2020\|issn=2168-8184\|doi=10.7759/cureus.8819}}<br>- "This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0"</ref>		File:Histopathology of eosinophilic silent gonadotroph pituitary adenoma.jpg\|A silent gonadotroph pituitary adenoma which is in this case is eosinophilic (contrary to normal, basophilic, gonadotroph cells).<ref>{{cite journal\|last1=Gaballa\|first1=Salem\|last2=Lindsay\|first2=Jane\|last3=AlJaf\|first3=Avan\|last4=Hlaing\|first4=Kyaw M\|last5=Patel\|first5=Kashyap\|title=Acute Unilateral Oculomotor Nerve Palsy as the Initial Presenting Sign of Nonfunctioning Apoplectic Gonadotroph Adenoma\|journal=Cureus\|year=2020\|issn=2168-8184\|doi=10.7759/cureus.8819}}<br>- "This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0"</ref>
	</gallery>		</gallery>

			===Microscopy report===
			In normal autopsy:
			{\|class=wikitable
			\| Adenohypophysis and neurohypophysis with no focal changes.
			\|}
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Mikael Häggström: /* Microscopic evaluation */ /

2020-10-01T16:48:31Z

Microscopic evaluation: /

← Older revision		Revision as of 12:48, 1 October 2020
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	File:Pie chart of incidences of silent pituitary adenomas.png\|Incidences of silent pituitary adenomas.<ref>{{cite journal\|last1=Drummond\|first1=Juliana\|last2=Roncaroli\|first2=Federico\|last3=Grossman\|first3=Ashley B\|last4=Korbonits\|first4=Márta\|title=Clinical and Pathological Aspects of Silent Pituitary Adenomas\|journal=The Journal of Clinical Endocrinology & Metabolism\|volume=104\|issue=7\|year=2019\|pages=2473–2489\|issn=0021-972X\|doi=10.1210/jc.2018-00688}}<br>- "This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/)"</ref>		File:Pie chart of incidences of silent pituitary adenomas.png\|Incidences of silent pituitary adenomas.<ref>{{cite journal\|last1=Drummond\|first1=Juliana\|last2=Roncaroli\|first2=Federico\|last3=Grossman\|first3=Ashley B\|last4=Korbonits\|first4=Márta\|title=Clinical and Pathological Aspects of Silent Pituitary Adenomas\|journal=The Journal of Clinical Endocrinology & Metabolism\|volume=104\|issue=7\|year=2019\|pages=2473–2489\|issn=0021-972X\|doi=10.1210/jc.2018-00688}}<br>- "This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/)"</ref>
	File:Histopathology of eosinophilic silent gonadotroph pituitary adenoma.jpg\|A silent gonadotroph pituitary adenoma which is in this case is eosinophilic (contrary to normal, basophilic, gonadotroph cells).<ref>{{cite journal\|last1=Gaballa\|first1=Salem\|last2=Lindsay\|first2=Jane\|last3=AlJaf\|first3=Avan\|last4=Hlaing\|first4=Kyaw M\|last5=Patel\|first5=Kashyap\|title=Acute Unilateral Oculomotor Nerve Palsy as the Initial Presenting Sign of Nonfunctioning Apoplectic Gonadotroph Adenoma\|journal=Cureus\|year=2020\|issn=2168-8184\|doi=10.7759/cureus.8819}}<br>- "This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0"</ref>		File:Histopathology of eosinophilic silent gonadotroph pituitary adenoma.jpg\|A silent gonadotroph pituitary adenoma which is in this case is eosinophilic (contrary to normal, basophilic, gonadotroph cells).<ref>{{cite journal\|last1=Gaballa\|first1=Salem\|last2=Lindsay\|first2=Jane\|last3=AlJaf\|first3=Avan\|last4=Hlaing\|first4=Kyaw M\|last5=Patel\|first5=Kashyap\|title=Acute Unilateral Oculomotor Nerve Palsy as the Initial Presenting Sign of Nonfunctioning Apoplectic Gonadotroph Adenoma\|journal=Cureus\|year=2020\|issn=2168-8184\|doi=10.7759/cureus.8819}}<br>- "This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0"</ref>
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Mikael Häggström: Started

2020-10-01T16:48:02Z

Started

New page

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|author1=[[User:Mikael Häggström|Mikael Häggström]]
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}}

==Microscopic evaluation==
*Look for '''cellular expansions'''
*If present, distinguish it as '''hyperplasia or neoplasia'''. If uncertain, by using reticulin immunohistochemistry, hyperplasia will show a preserved reticulin meshwork, whereas pituitary adenomas have disruption of it.<ref name="Al-BrahimAsa2006">{{cite journal|last1=Al-Brahim|first1=N Y Y|last2=Asa|first2=S L|title=My approach to pathology of the pituitary gland|journal=Journal of Clinical Pathology|volume=59|issue=12|year=2006|pages=1245–1253|issn=0021-9746|doi=10.1136/jcp.2005.031187}}</ref>
:*For '''adenomas''', unless otherwise indicated by the medical history, will generally by definition be of the silent type. Basophilic or acidophilic staining may give a clue about the subtype, but immunohistochemistry is generally required.
<gallery>
File:Pie chart of incidences of silent pituitary adenomas.png|Incidences of silent pituitary adenomas.<ref>{{cite journal|last1=Drummond|first1=Juliana|last2=Roncaroli|first2=Federico|last3=Grossman|first3=Ashley B|last4=Korbonits|first4=Márta|title=Clinical and Pathological Aspects of Silent Pituitary Adenomas|journal=The Journal of Clinical Endocrinology & Metabolism|volume=104|issue=7|year=2019|pages=2473–2489|issn=0021-972X|doi=10.1210/jc.2018-00688}}<br>- "This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/)"</ref>
File:Histopathology of eosinophilic silent gonadotroph pituitary adenoma.jpg|A silent gonadotroph pituitary adenoma which is in this case is eosinophilic (contrary to normal, basophilic, gonadotroph cells).<ref>{{cite journal|last1=Gaballa|first1=Salem|last2=Lindsay|first2=Jane|last3=AlJaf|first3=Avan|last4=Hlaing|first4=Kyaw M|last5=Patel|first5=Kashyap|title=Acute Unilateral Oculomotor Nerve Palsy as the Initial Presenting Sign of Nonfunctioning Apoplectic Gonadotroph Adenoma|journal=Cureus|year=2020|issn=2168-8184|doi=10.7759/cureus.8819}}<br>- "This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0"</ref>
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