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| {{Top | | <noinclude>{{Top |
| |author1=[[User:Mikael Häggström|Mikael Häggström]] | | |author1=[[User:Mikael Häggström|Mikael Häggström]] |
| |author2= | | |author2= |
| }} | | }} |
| {{Fixation - standard}} | | {{Fixation - standard}} |
| {{Fixation - general notes}} | | {{Fixation - general notes}}</noinclude> |
| ==Hysterectomy sampling== | | ==Hysterectomy sampling== |
| A '''[[Hysterectomy|regular hysterectomy grossing]]''' is performed, but with the following sampling:<ref>{{cite web|url=https://voices.uchicago.edu/grosspathology/gyne/uterus-endometrial-hyperplasia/|title=Gross Pathology Manual|website=The University of Chicago Department of Pathology|author=Nicole Cipriani|date=2020-06-22}}</ref> | | A '''[[Hysterectomy|regular hysterectomy grossing]]''' is performed, but with the following sampling:<ref>{{cite web|url=https://voices.uchicago.edu/grosspathology/gyne/uterus-endometrial-hyperplasia/|title=Gross Pathology Manual|website=The University of Chicago Department of Pathology|author=Nicole Cipriani|date=2020-06-22}}</ref> |
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| ==Microscopic evaluation== | | ==Microscopic evaluation== |
| [[File:Endometrial histopathologies and cytopathologies.jpg|thumb|400px|Histopathologic and cytopathologic images.<br>(A) proliferative endometrium (Left: HE × 400) and proliferative endometrial cells (Right: HE × 100)<br>(B) secretory endometrium (Left: HE × 10) and secretory endometrial cells (Right: HE × 10)<br>(C) atrophic endometrium (Left: HE × 10) and atrophic endometrial cells (Right: HE × 10)<br>(D) mixed endometrium (Left: HE × 10) and mixed endometrial cells (Right: HE × 10)<br>(E): endometrial atypical hyperplasia (Left: HE × 10) and endometrial atypical cells (Right: HE × 200)<br>(F) endometrial carcinoma (Left: HE × 400) and endometrial cancer cells (Right: HE × 400).]]
| | *Look for signs of atypia or malignancy: |
| *Look for signs of atypia or malignancy. | | {{Endometrial hyperplasia, atypia and/or malignancy}} |
| <gallery mode=packed>
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| File:Histopathology of complex hyperplasia without atypia.jpg|'''Complex hyperplasia without atypia''': Cystically dilated endometrial glands lined by a single layer of columnar epithelium.<ref>{{cite journal|last1=Rao|first1=Shalinee|last2=Sundaram|first2=Sandhya|last3=Narasimhan|first3=Raghavan|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India|journal=Indian Journal of Medical and Paediatric Oncology|volume=30|issue=4|year=2009|pages=131|issn=0971-5851|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Cystically-dilated-endometrial-glands-lined-by-a-single-layer-of-columnar-epithelium_fig1_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>
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| File:Histopathology of complex hyperplasia with atypia.jpg|'''Complex hyperplasia with atypia''': Closely packed endometrial glands with sparse intervening stroma and stratification of the lining epithelium. Epithelial cells show cytological atypia with high nucleocytoplasmic ratio, irregular clumping of nuclear chromatin, and mitotic figures.<ref>{{cite journal|last1=Rao|first1=Shalinee|last2=Sundaram|first2=Sandhya|last3=Narasimhan|first3=Raghavan|title=Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India|journal=Indian Journal of Medical and Paediatric Oncology|volume=30|issue=4|year=2009|pages=131|issn=0971-5851|doi=10.4103/0971-5851.65335}}<br>- [https://www.researchgate.net/figure/Closely-packed-endometrial-glands-with-sparse-intervening-stroma-and-stratification-of_fig2_46256480 Figure- available via license: Creative Commons Attribution 2.0 Generic]</ref>
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| </gallery>
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| ==Reporting== | | ==Reporting== |
| Most importantly: | | Most importantly: |
| *Presence or absence of atypia. | | *Presence or absence of atypia. |
| {{Reporting}} | | <noinclude>{{Reporting}} |
| {{Bottom}} | | {{Bottom}}</noinclude> |