Skin: Difference between revisions
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{{Top | <noinclude>{{Top | ||
|author1=[[User:Mikael Häggström|Mikael Häggström]] | |author1=[[User:Mikael Häggström|Mikael Häggström]] | ||
|author2= | |author2= | ||
}} | }} | ||
For skin specimens in general: | |||
{{Fixation - standard}} | {{Fixation - standard}} | ||
{{Fixation - general notes}} | {{Fixation - general notes}} | ||
*Suspected '''immunologic disease''':<ref name="ChhabraMinz2012">Page 678 in: {{cite journal|last1=Chhabra|first1=Seema|last2=Minz|first2=RanjanaWalker|last3=Saikia|first3=Biman|title=Immunofluorescence in dermatology|journal=Indian Journal of Dermatology, Venereology, and Leprology|volume=78|issue=6|year=2012|pages=677|issn=0378-6323|doi=10.4103/0378-6323.102355|url=https://pdfs.semanticscholar.org/23d0/148dbe342a93e0bc65a6a2e31040a89113ba.pdf}}</ref> Fixation for immunofluorescence, with for example [[Michel's solution]].<ref name=kvast/> ''For details, see [[immunofluorescense of skin tissues]]'' | *Suspected '''immunologic disease''':<ref name="ChhabraMinz2012">Page 678 in: {{cite journal|last1=Chhabra|first1=Seema|last2=Minz|first2=RanjanaWalker|last3=Saikia|first3=Biman|title=Immunofluorescence in dermatology|journal=Indian Journal of Dermatology, Venereology, and Leprology|volume=78|issue=6|year=2012|pages=677|issn=0378-6323|doi=10.4103/0378-6323.102355|url=https://pdfs.semanticscholar.org/23d0/148dbe342a93e0bc65a6a2e31040a89113ba.pdf}}</ref> Fixation for immunofluorescence, with for example [[Michel's solution]].<ref name=kvast>{{cite web|url=http://www.svfp.se/foreningar/uploads/L15178/kvast/hud/Handlaggning%20av%20hudprover%20%20provtagningsanvisningar%20utskarningsprinciper%20och%20snittning%2020150325.pdf|title=Handläggning av hudprover – provtagningsanvisningar, utskärningsprinciper och snittning (Handling of skin samples - Instructions for sampling, cutting and incision|author=Katarzyna Lundmark, Krynitz, Ismini Vassilaki, Lena Mölne, Annika Ternesten Bratel|accessdate=2019-09-09|website=KVAST (Swedish Society of Pathology)}}</ref> ''For details, see [[immunofluorescense of skin tissues]]'' | ||
==Presentations== | ==Presentations== | ||
<gallery> | <gallery> | ||
File:Dark skin focalities.jpg|link=Dark skin focalities|[[Dark skin focalities]] | File:Dark skin focalities.jpg|link=Dark skin focalities|[[Dark skin focalities]] | ||
File:Gross pathology of cystic nodular hidradenoma.jpg|link=Skin cysts|[[Skin cysts]] | |||
</gallery> | </gallery> | ||
===Most common requests=== | ===Most common requests=== | ||
*[[Suspected malignant skin excisions]] | *[[Suspected malignant skin excisions]] | ||
:*[[Melanoma]] | :*[[Melanoma in situ]] | ||
:*[[Invasive melanoma of the skin]] | |||
:*[[Basal-cell carcinoma]] | :*[[Basal-cell carcinoma]] | ||
:*[[Squamous-cell carcinoma of the skin]] | :*[[Squamous-cell carcinoma of the skin]] | ||
*[[ | *[[Dermatitis]] | ||
*[[Benign non-inflammatory skin conditions]] | *[[Benign non-inflammatory skin conditions]] | ||
:*[[Dysplastic nevus]] | :*[[Dysplastic nevus]] | ||
*[[Wound]] | |||
{{Gross processing of skin excisions}} | {{Gross processing of skin excisions}} | ||
</noinclude> | |||
==Microscopic evaluation== | ==Microscopic evaluation== | ||
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*Is it a '''[[suspected malignant skin excisions|suspected malignant skin excision]]'''? If not: | *Is it a '''[[suspected malignant skin excisions|suspected malignant skin excision]]'''? If not: | ||
*If primarily inflammatory, evaluate as '''[[dermatitis]]'''. If none of these, evaluate as: | *If primarily inflammatory, evaluate as '''[[dermatitis]]'''. If none of these, evaluate as: | ||
*[[Benign non-inflammatory skin conditions]] | *'''[[Benign non-inflammatory skin conditions]]''', including '''[[skin cyst]]s''' | ||
{{Bottom}} | In '''intraoperative''' consultations by frozen section, it is generally sufficient to report clear margins if present, and specification of the type of tumor can be deferred to permanent sections. | ||
==Reporting== | |||
''Preferably see specific articles from algorithm in section above.'' | |||
*Optionally, the presence of a keratinized squamous epithelium. | |||
*Any abnormalities, generally preceded by location in terms of epidermal, dermal or more specific layers thereof. | |||
*If malignant: | |||
:*Degree of differentiation | |||
:*Radicality/Least distance to a margin | |||
:*Perineural or vascular invasion if present | |||
<noinclude>{{Bottom}}</noinclude> | |||