Dermatitis: Difference between revisions

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Mikael Häggström (talk | contribs)
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====Multinucleated giant cells====
====Multinucleated giant cells====
[[File:Histopathology of suture granuloma.jpg|thumb|220px|Suture granuloma, with multinucleated giant cells surrounding (grey) suture material.]]
*Look for '''foreign bodies''', conferring a diagnosis of ''foreign body granuloma''.
*Look for '''foreign bodies''', conferring a diagnosis of ''foreign body granuloma''.
*Look for any specific '''appearance''' of the giant cells:
*Look for any specific '''appearance''' of the giant cells.
<gallery>
*Look for '''relation''' to adnexae or other particular structures.
File:Touton giant cell (annotated).jpg|Touton giant cell
<gallery mode=packed heights=220>
File:Histopathology of suture granuloma.jpg|thumb|220px|Foreign body: '''Suture''' granuloma, with multinucleated giant cells surrounding (grey) suture material.]]
File:Touton giant cell (annotated).jpg|Appearance: A '''Touton giant cell''' contains a ring of nuclei surrounding a central homogeneous cytoplasm, with foamy cytoplasm surrounding the nuclei.<ref>{{cite book | last = Grant-Kels | first = Jane | title = Color Atlas of Dermatopathology | publisher = Informa Healthcare | location = City | year = 2007 | isbn = 978-0-8493-3794-9 | pages = 107, 119 }}</ref><ref>{{cite journal |last1=Carmen Gómez-Mateo |first1=Maria |last2=Monteagudo |first2=Carlos |date=2013 |title=Nonepithelial skin tumors with multinucleated giant cells |url=http://www.semdiagpath.com/article/S0740-2570(12)00009-3/fulltext |journal=Seminars in Diagnostic Pathology |volume=30 |issue=1 |pages=58–72 |pmid=23327730 |doi=10.1053/j.semdp.2012.01.004}}</ref> The central cytoplasm (surrounded by the nuclei) may be both amphophilic and eosinophilic.<ref>{{cite journal |last1=Sequeira |first1=Fiona |last2=Gandhi |first2=Suneil |date=2012 |title=Named cells in dermatology |url=http://www.ijdvl.com/article.asp?issn=0378-6323;year=2012;volume=78;issue=2;spage=207;epage=216;aulast=Sequeira |journal=Indian Journal of Dermatology, Venereology and Leprology |volume=78 |issue=2 |pages=207–16 |doi=10.4103/0378-6323.93650 |pmid=22421663}}</ref>
File:Histopathology of granulomatous folliculitis.jpg|thumb|Relation: '''Folliculitis''' with multinucleated giant cells surrounding a hair follicle.
</gallery>
</gallery>
A '''Touton giant cell''' contains a ring of nuclei surrounding a central homogeneous cytoplasm, with foamy cytoplasm surrounding the nuclei.<ref>{{cite book | last = Grant-Kels | first = Jane | title = Color Atlas of Dermatopathology | publisher = Informa Healthcare | location = City | year = 2007 | isbn = 978-0-8493-3794-9 | pages = 107, 119 }}</ref><ref>{{cite journal |last1=Carmen Gómez-Mateo |first1=Maria |last2=Monteagudo |first2=Carlos |date=2013 |title=Nonepithelial skin tumors with multinucleated giant cells |url=http://www.semdiagpath.com/article/S0740-2570(12)00009-3/fulltext |journal=Seminars in Diagnostic Pathology |volume=30 |issue=1 |pages=58–72 |pmid=23327730 |doi=10.1053/j.semdp.2012.01.004}}</ref> The central cytoplasm (surrounded by the nuclei) may be both amphophilic and eosinophilic.<ref>{{cite journal |last1=Sequeira |first1=Fiona |last2=Gandhi |first2=Suneil |date=2012 |title=Named cells in dermatology |url=http://www.ijdvl.com/article.asp?issn=0378-6323;year=2012;volume=78;issue=2;spage=207;epage=216;aulast=Sequeira |journal=Indian Journal of Dermatology, Venereology and Leprology |volume=78 |issue=2 |pages=207–16 |doi=10.4103/0378-6323.93650 |pmid=22421663}}</ref>
 
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