Dermatitis: Difference between revisions

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[[File:Histopathology of leprosy.jpg|thumb|Leprosy]]
[[File:Histopathology of leprosy.jpg|thumb|Leprosy]]
These include bacterial infections including leprosy, and the sample should therefore be stained with Ziel-Neelsen, acid fast stains, Gomori methenamine silver, PAS, and Fite stains.<ref name="Alsaad2005"/> If negative, an unspecific lymphohistocytic dermatosis may be caused by drug reactions and viral infections.<ref name="Alsaad2005"/><ref group="notes" name="not-otherwise-specified"/>
These include bacterial infections including leprosy, and the sample should therefore be stained with Ziel-Neelsen, acid fast stains, Gomori methenamine silver, PAS, and Fite stains.<ref name="Alsaad2005"/> If negative, an unspecific lymphohistocytic dermatosis may be caused by drug reactions and viral infections.<ref name="Alsaad2005"/><ref group="notes" name="not-otherwise-specified"/>
=====Granulomatous inflammation=====
{{further|Granulomatous skin inflammation}}
Granulomatous inflammation is defined by the presence of mononuclear leukocytes, specifically histiocytes, appearing as epithelioid cells with round to oval nuclei, often with irregular contours and abundant granular eosinophilic cytoplasm with indistinct cell borders. They may also coalesce to form multinucleated giant cells.<ref name="ShahPritt2017">{{cite journal|last1=Shah|first1=Kabeer K.|last2=Pritt|first2=Bobbi S.|last3=Alexander|first3=Mariam P.|title=Histopathologic review of granulomatous inflammation|journal=Journal of Clinical Tuberculosis and Other Mycobacterial Diseases|volume=7|year=2017|pages=1–12|issn=24055794|doi=10.1016/j.jctube.2017.02.001}}</ref>
<gallery mode=packed heights=220>
File:Histopathology of suture granuloma.jpg|Foreign body: '''Suture''' granuloma, with multinucleated giant cells surrounding (grey) suture material.
</gallery>


====Neutrophilic infiltrate====
====Neutrophilic infiltrate====
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| [[File:Cutaneous small-vessel vasculitis.jpg|190px]]
| [[File:Cutaneous small-vessel vasculitis.jpg|190px]]
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====Granulomatous inflammation====
{{further|Granulomatous skin inflammation}}
Granulomatous inflammation is defined by the presence of mononuclear leukocytes, specifically histiocytes, appearing as epithelioid cells with round to oval nuclei, often with irregular contours and abundant granular eosinophilic cytoplasm with indistinct cell borders. They may also coalesce to form multinucleated giant cells.<ref name="ShahPritt2017">{{cite journal|last1=Shah|first1=Kabeer K.|last2=Pritt|first2=Bobbi S.|last3=Alexander|first3=Mariam P.|title=Histopathologic review of granulomatous inflammation|journal=Journal of Clinical Tuberculosis and Other Mycobacterial Diseases|volume=7|year=2017|pages=1–12|issn=24055794|doi=10.1016/j.jctube.2017.02.001}}</ref>
<gallery mode=packed heights=220>
File:Histopathology of suture granuloma.jpg|Foreign body: '''Suture''' granuloma, with multinucleated giant cells surrounding (grey) suture material.
</gallery>


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