Evaluation of suspected malignancies: Difference between revisions
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+Tumor types |
→Overall diagnosis: Expanded |
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Two relatively common forms of tumors are: | Two relatively common forms of tumors are: | ||
<gallery mode=packed> | <gallery mode=packed> | ||
File:Non-proliferative versus proliferative colonic crypts.jpg|''' | File:Non-proliferative versus proliferative colonic crypts.jpg|'''Gland-like tumors''' (image shows normal colonic crypt compared to an adenoma) | ||
File:Histopathology of leiomyoma of the ileocecal valve.jpg|''' | File:Histopathology of leiomyoma of the ileocecal valve.jpg|'''Spindle-cell tumors''' (image shows a leiomyoma) | ||
</gallery> | </gallery> | ||
'''Gland-like tumors''' are mainly evaluated for cellular atypia, architectural dysplasia and invasion, and thereby classified into the following main categories: | |||
*'''Hyperplastic''' lesions, lacking significant atypia | |||
*'''Adenomas''', which can range from mild to high-grade dysplastic, yet are not invasive | |||
*'''Adenocarcinomas''', with the main criterion being invasiveness. Evaluate specifically by location when possible: | |||
:*[[Colorectal adenocarcinoma]] | |||
:*[[Prostate adenocarcinoma]] | |||
:*[[Lung adenocarcinoma]] | |||
:*[[Bladder adenocarcinoma]] | |||
:*[[Esophageal adenocarcinoma]] | |||
:*[[Endometrial adenocarcinoma]] | |||
For '''Spindle-cell tumors''', the shape of the nuclei is a clue to the diagnosis, with the following tendency: | |||
*Pointed on both ends: True fibroblastic tumors | |||
*Pointed on one end and blunted on the other ("bullet-shaped"): Neural | |||
*Blunted on both ends ("cigar-shaped"): Smooth muscle | |||
*Triangular: Myofibroblastic | |||
==Staging== | ==Staging== | ||