Immunohistochemistry: Difference between revisions

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==Immunohistochemistry ordering==

The main approaches to immunohistochemistry ordering are:

*Look for a specified '''panel''' for the presentation at hand. For example, for an undifferentiated tumor with no clear lineage differentiation, an initial panel of CK, S100, vimentin and LCA can be used.<ref name="pmid25427040">{{cite journal| author=Lin F, Liu H| title=Immunohistochemistry in undifferentiated neoplasm/tumor of uncertain origin. | journal=Arch Pathol Lab Med | year= 2014 | volume= 138 | issue= 12 | pages= 1583-610 | pmid=25427040 | doi=10.5858/arpa.2014-0061-RA | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25427040 }} </ref>

*Coming up with the most relevant '''differential diagnoses''' for the case at hand, and find the immunohistochemistry stains that best distinguish them. These can usually be found at the entries for each condition in '''[https://www.pathologyoutlines.com/ Pathology Outlines]''', or you can pay for a subscription to '''ImmunoQuery'''{{ImmunoQuery COI declaration}}, enter each differential diagnosis there, and have it generate the best immunohistochemistry panel.

==Immunohistochemistry evaluation==

The main methods for evaluating immunohistochemistry results are:

*Looking up each differential diagnosis at for example '''[https://www.pathologyoutlines.com/ Pathology Outlines]''' and comparing their expected staining to see which entity is most likely.

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+==Immunohistochemistry ordering==
+The main approaches to immunohistochemistry ordering are:
+*Look for a specified '''panel''' for the presentation at hand. For example, for an undifferentiated tumor with no clear lineage differentiation, an initial panel of CK, S100, vimentin and LCA can be used.<ref name="pmid25427040">{{cite journal| author=Lin F, Liu H| title=Immunohistochemistry in undifferentiated neoplasm/tumor of uncertain origin. | journal=Arch Pathol Lab Med | year= 2014 | volume= 138 | issue= 12 | pages= 1583-610 | pmid=25427040 | doi=10.5858/arpa.2014-0061-RA | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25427040  }} </ref>
+*Coming up with the most relevant '''differential diagnoses''' for the case at hand, and find the immunohistochemistry stains that best distinguish them. These can usually be found at the entries for each condition in '''[https://www.pathologyoutlines.com/ Pathology Outlines]''', or you can pay for a subscription to '''ImmunoQuery'''{{ImmunoQuery COI declaration}}, enter each differential diagnosis there, and have it generate the best immunohistochemistry panel.
+==Immunohistochemistry evaluation==
 The main methods for evaluating immunohistochemistry results are:
 *Looking up each differential diagnosis at for example '''[https://www.pathologyoutlines.com/ Pathology Outlines]''' and comparing their expected staining to see which entity is most likely.

Immunohistochemistry: Difference between revisions

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