Blood compatibility testing: Difference between revisions
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* '''Step 3''': Annotated in purple. Repeating the same for each reference cell row with negative reaction. | * '''Step 3''': Annotated in purple. Repeating the same for each reference cell row with negative reaction. | ||
* '''Step 4''': Discounting antigens that were absent in all or almost all reactive cases (here marked with \). These are often antigens with low prevalence, and while there is a possibility of such antibodies being produced, they are generally not the type that is responsible for the reactivity at hand. | * '''Step 4''': Discounting antigens that were absent in all or almost all reactive cases (here marked with \). These are often antigens with low prevalence, and while there is a possibility of such antibodies being produced, they are generally not the type that is responsible for the reactivity at hand. | ||
* '''Step 5''': Comparing the remaining possible antigens for a most likely culprit (in this case Fy<sup>a</sup>), and selectively ruling out significant differential antigens, such as with the shown additional donor cell type that is known to not contain Fy<sup>a</sup> but contains C and Jk<sup>a</sup> | * '''Step 5''': Comparing the remaining possible antigens for a most likely culprit (in this case Fy<sup>a</sup>), and selectively ruling out significant differential antigens, such as with the shown additional donor cell type that is known to not contain Fy<sup>a</sup> but contains C and Jk<sup>a</sup>. | ||
In this case, the antibody panel shows that anti-Fy<sup>a</sup> antibodies are present. This indicates that donor blood typed to be negative for the Fy<sup>a</sup> antigen must be used. Still, if a subsequent cross-matching shows reactivity, additional testing should be done against previously discounted antigens (in this case potentially E, K, Kp<sup>a</sup> and/or Lu<sup>a</sup>).<ref name=UtahU/> | In this case, the antibody panel shows that anti-Fy<sup>a</sup> antibodies are present. This indicates that donor blood typed to be negative for the Fy<sup>a</sup> antigen must be used. Still, if a subsequent cross-matching shows reactivity, additional testing should be done against previously discounted antigens (in this case potentially E, K, Kp<sup>a</sup> and/or Lu<sup>a</sup>).<ref name=UtahU/> | ||
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