Suspected blasts on peripheral blood smear: Difference between revisions
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===Suspect or exclude acute promyelocytic leukemia (APL)=== | ===Suspect or exclude acute promyelocytic leukemia (APL)=== | ||
[[File:Cytology of acute promyelocytic leukemia, annotated.png|thumb|350px|Main features of '''acute promyelocytic leukemia''' (APL).<ref>Image by Mikael Häggström, MD. Reference for findings: {{cite web|url=https://www.pathologyoutlines.com/topic/leukemiaapl.html|title=APL with PML-RARA|author=Syed Zaidi, M.D.|website=APL with PML-RARA}} Last author update: 1 February 2013<br>Source image: [[:File:Faggot cell in AML-M3.jpg]] from [http://peir2.path.uab.edu/pdl/dbra.cgi?uid=default&view_search=1 PEIR Digital Library (Pathology image database)] (Public Domain)</ref>]] | [[File:Cytology of acute promyelocytic leukemia, annotated.png|thumb|350px|Main features of '''acute promyelocytic leukemia''' (APL).<ref>Image by Mikael Häggström, MD. Reference for findings: {{cite web|url=https://www.pathologyoutlines.com/topic/leukemiaapl.html|title=APL with PML-RARA|author=Syed Zaidi, M.D.|website=APL with PML-RARA}} Last author update: 1 February 2013<br>Source image: [[:File:Faggot cell in AML-M3.jpg]] from [http://peir2.path.uab.edu/pdl/dbra.cgi?uid=default&view_search=1 PEIR Digital Library (Pathology image database)] (Public Domain)</ref>]] | ||
[[File:Peripheral blood smear of acute promyelocytic leukemia, hypogranular variant.png|thumb|400px|<ref>Image by Mikael Häggström, MD. Source for findings: {{cite web|url=https://www.pathologyoutlines.com/topic/leukemiaapl.html|title=Bone marrow neoplastic, APL with PML-RARA|website=Pathology Outlines|author=Syed Zaidi, M.D.}} Last author update: 1 February 2013 Last staff update: 29 November 2022</ref>]] | [[File:Peripheral blood smear of acute promyelocytic leukemia, hypogranular variant.png|thumb|400px|Although cells with irregular nuclei may look similar to benign monocytes, there should be precursor cell (or "blast") features as shown.<ref>Image by Mikael Häggström, MD. Source for findings: {{cite web|url=https://www.pathologyoutlines.com/topic/leukemiaapl.html|title=Bone marrow neoplastic, APL with PML-RARA|website=Pathology Outlines|author=Syed Zaidi, M.D.}} Last author update: 1 February 2013 Last staff update: 29 November 2022</ref>]] | ||
APL typically shows blast cells with ample amount of cytoplasmic granules and Auer rods. However, it may also have a hypogranular variant with very scant Auer rods. | APL typically shows blast cells with ample amount of cytoplasmic granules and Auer rods. However, it may also have a hypogranular variant with very scant Auer rods. | ||