Dermatitis: Difference between revisions
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| Includes the rare disease of primary mastocytosis.<ref name="Alsaad2005"/><ref group="notes" name="not-otherwise-specified"/> | | Includes the rare disease of primary mastocytosis.<ref name="Alsaad2005"/><ref group="notes" name="not-otherwise-specified"/> | ||
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| | | [[File:Urticaria near navel.jpg|190px]] | ||
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====Neutrophilic infiltrate==== | ====Neutrophilic infiltrate==== | ||
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! Main conditions<ref name="Alsaad2005"/> !! Characteristics !! Micrograph !! Photograph | |||
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! Urticaria, neutrophil predominant | |||
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*Interstitial location<ref name="BarzilaiSagi2017"/> | |||
*Relatively dense infiltrate<ref name="BarzilaiSagi2017"/> | |||
*Mast cells are relatively sparse, potentially demonstrated with special stains, preferably tryptase stain.<ref name="BarzilaiSagi2017"/> | |||
*Extravasated erythrocytes are present in about 50% of the cases <ref name="BarzilaiSagi2017"/> | |||
*No vasculitis.<ref name="BarzilaiSagi2017"/> | |||
| [[File:Micrograph of neutrophilic urticarial dermatosis.jpg|190px]] | |||
| [[File:Neutrophilic urticarial dermatosis.jpg|190px]] | |||
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! Dermatitis herpetiformis | |||
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*Subepidermal vesicles and blisters associated with accumulation of neutrophils at the papillary tips.<ref name="AntigaCaproni2015">{{cite journal|last1=Antiga|first1=Emiliano|last2=Caproni|first2=Marzia|title=The diagnosis and treatment of dermatitis herpetiformis|journal=Clinical, Cosmetic and Investigational Dermatology|year=2015|pages=257|issn=1178-7015|doi=10.2147/CCID.S69127}}</ref> | |||
*Sometimes presence of eosinophils, giving an appearance similar to bullous pemphigoid.<ref name="AntigaCaproni2015"/> | |||
*The histopathology is unspecific in approximately 35%–40% of the cases,<ref name="AntigaCaproni2015"/> and direct immunofluorescence is needed, showing deposition of IgA in the papillary dermis in a granular or fibrillar pattern.<ref>{{cite web|url=https://www.ncbi.nlm.nih.gov/books/NBK493163/|title=Dermatitis Herpetiformis|author=Huma A. Mirza; Amani Gharbi; William Gossman.|website=StatPearls at National Center for Biotechnology Information}} Last Update: July 11, 2019.</ref> | |||
| [[File:Micrograph of dermatitis herpetiformis.jpg|190px]] | |||
| [[File:Dermatitis herpetiformis.jpg|190px]] | |||
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! Early linear IgA bullous dermatosis | |||
| Subepidermal blister formation.<ref>{{cite journal|last1=Saleem|first1=Maryam|last2=Iftikhar|first2=Hassaan|title=Linear IgA Disease: A Rare Complication of Vancomycin|journal=Cureus|year=2019|issn=2168-8184|doi=10.7759/cureus.4848}}</ref> | |||
| [[File:Micrograph of linear IgA bullous dermatosis.jpg|190px]] | |||
| [[File:Linear IgA bullous dermatosis.jpg|190px]] | |||
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! Early febrile neutrophilic dermatosis (Sweet's syndrome) | |||
| Neutrophilic and lymphohistiocytic infiltrate and edema.<ref name="Casarin CostaVirgens2017">{{cite journal|last1=Casarin Costa|first1=Jose Ricardo|last2=Virgens|first2=Anangelica Rodrigues|last3=de Oliveira Mestre|first3=Luisa|last4=Dias|first4=Natasha Favoretto|last5=Samorano|first5=Luciana Paula|last6=Valente|first6=Neusa Yuriko Sakai|last7=Festa Neto|first7=Cyro|title=Sweet Syndrome: Clinical Features, Histopathology, and Associations of 83 Cases|journal=Journal of Cutaneous Medicine and Surgery|volume=21|issue=3|year=2017|pages=211–216|issn=1203-4754|doi=10.1177/1203475417690719}}</ref> | |||
| [[File:Sweet's syndrome pathology.jpg|190px]] | |||
| [[File:Sweet's syndrome Crohn's disease.gif|190px]] | |||
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! Connective tissue disorders | |||
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*Usually associated with epidermal changes.<ref name="Alsaad2005"/> (Systemic lupus erythematosis pictured) | |||
| [[File:Histopathology of systemic lupus erythematosus.jpg|190px]] | |||
| [[File:Butterfly rash of lupus erythematosus.jpg|190px]] | |||
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{{Bottom}} | {{Bottom}} | ||