Dermatitis: Difference between revisions

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{| class="wikitable"

|+Psoriasiform dermatitis<ref name="Alsaad2005"/>

! Condition !! Hyperkeratosis !! Parakeratosis !! Acanthosis !! Suprapapillary plate ~~!! Microabscess formation~~ !! Granular cell layer changes !! Spinous cell layer changes !! Basal cell layer changes || Micrograph || Photograph

! Condition !! Hyperkeratosis !! Parakeratosis !! Acanthosis !! Suprapapillary plate !! Granular cell layer changes !! Spinous cell layer changes !! Basal cell layer changes !! Other distinctive feature !! Micrograph !! Photograph

|-

! Psoriasis

| Present || Diffuse || Regular || Thin || Present || Decreased or absent || Increased mitoses; minimal spongiosis<br>Clubbed rete pegs<ref name="Kunz2009">{{cite journal|vauthors=Kunz M, Ibrahim SM |title=Cytokines and cytokine profiles in human autoimmune diseases and animal models of autoimmunity|journal=Mediators of Inflammation|year=2009|volume=2009|pages=1–20|pmid=19884985|pmc=2768824|doi=10.1155/2009/979258}}</ref> <ref name="Raychaudhuri2014">{{cite journal |vauthors=Raychaudhuri SK, Maverakis E, Raychaudhuri SP |title=Diagnosis and classification of psoriasis|journal=Autoimmunity Reviews|volume=13|issue=4–5|pages=490–5|date=January 2014 |pmid=24434359|doi=10.1016/j.autrev.2014.01.008}}</ref> || Absent

|

*Microabscesses

| [[File:Micrograph of psoriasis vulgaris.jpg|120px]] || [[File:Psoriasis on elbow.jpg|120px]]

|-

! Psoriasiform drug reaction

| Present || Focal || Regular and irregular || Normal or thick || Absent || Normal || Spongiosis; eosinophilic infiltrate || Inflammatory cells; Civatte bodies

| Present || Focal || Regular and irregular || Normal or thick || Absent || Normal || Spongiosis; eosinophilic infiltrate || Inflammatory cells; Civatte bodies ||

|-

! Chronic allergic/contact and atopic dermatitis

| Present || Focal; crust may be present || Irregular || Normal or thick || Absent || Normal || Spongiosis; eosinophilic infiltrate || Absent

| Present || Focal; crust may be present || Irregular || Normal or thick || Absent || Normal || Spongiosis; eosinophilic infiltrate || Absent ||

|-

! Fungal infection

| Compact || Focal; crust may be present || Irregular || Normal or thick || Absent || Normal || Occasional neutrophiles; || –

| Compact || Focal; crust may be present || Irregular || Normal or thick || Absent || Normal || Occasional neutrophiles; || Absent ||

|-

! Lichen simplex chronicus

| Present || Focal; thick crust || Regular or irregular || Thin or thick || Absent || Thickened; hypergranulosis || ±minimal inflammatory infiltrate || –

| Present || Focal; thick crust || Regular or irregular || Thin or thick || Absent || Thickened; hypergranulosis || ±minimal inflammatory infiltrate || Absent ||

|-

! Scabies

| Present || Focal or diffuse || Irregular || Normal or thick || Absent || Normal || Inflammatory infiltrate; eosinophilic spongiosis || –

| Present || Focal or diffuse || Irregular || Normal or thick || Absent || Normal || Inflammatory infiltrate; eosinophilic spongiosis || Absent ||

|-

! Seborrheic dermatitis and HIV dermatitis

| Present || Focal || Irregular || Normal or thick || Absent || Normal || Spongiosis; lymphocytic and neutrophilic infiltrate || –

| Present || Focal || Irregular || Normal or thick || Absent || Normal || Spongiosis; lymphocytic and neutrophilic infiltrate || Absent ||

|-

! Pityriasis rubra pilaris

| Compact || Shoulder parakeratosis<ref group="notes">Parakeratotic mounds at the edge of follicular ostia.</ref>; alternating orthokeratosis and parakeratosis || Regular or irregular || Normal or thick || Absent || Normal || Spongiosis; lymphocytic infiltrate; rare acantholysis || Occasional vacuolar change

| Compact || Shoulder parakeratosis<ref group="notes">Parakeratotic mounds at the edge of follicular ostia.</ref>; alternating orthokeratosis and parakeratosis || Regular or irregular || Normal or thick || Absent || Normal || Spongiosis; lymphocytic infiltrate; rare acantholysis || Occasional vacuolar change ||

|-

! Pityriasis rosea

| Present || Focal || Irregular || Normal or thick || Absent || Normal || Small foci of spongiosis; lymphocytic infiltrate || Occasional necrotic keratinocytes

| Present || Focal || Irregular || Normal or thick || Absent || Normal || Small foci of spongiosis; lymphocytic infiltrate || Occasional necrotic keratinocytes ||

|-

! Syphilis

| Present || Focal || Regular or irregular || Normal or thick || Absent || Normal || Lymphocytes and neutrophils || Interface change

| Present || Focal || Regular or irregular || Normal or thick || Absent || Normal || Lymphocytes and neutrophils || Interface change ||

|-

! Pityriasis lichenoides chronica

| Present || Caps of parakeratosis || Irregular || Normal || Absent || Normal || Mild spongiosis, lymphocytic infiltrate; necrotic keratinocytes || Necrotic keratinocytes

| Present || Caps of parakeratosis || Irregular || Normal || Absent || Normal || Mild spongiosis, lymphocytic infiltrate; necrotic keratinocytes || Necrotic keratinocytes ||

|-

! Mycosis fungoides

| Present || Focal || Regular or irregular || Normal || Absent || Normal || Minimal or no spongiosis; ±Pautrier microabscess || Atypical lymphoid cells lining the dermo–epidermal junction

| Present || Focal || Regular or irregular || Normal || Absent || Normal || Minimal or no spongiosis; ±Pautrier microabscess || Atypical lymphoid cells lining the dermo–epidermal junction ||

| [[File:Histopathology of Pautrier microabscesses.jpg|thumb|120px|Pautrier microabscesses]]

|}

@@ Line 192: / Line 192: @@
 {| class="wikitable"
 |+Psoriasiform dermatitis<ref name="Alsaad2005"/>
-! Condition !! Hyperkeratosis !! Parakeratosis !! Acanthosis !! Suprapapillary plate !! Microabscess formation !! Granular cell layer changes !! Spinous cell layer changes !! Basal cell layer changes || Micrograph || Photograph
+! Condition !! Hyperkeratosis !! Parakeratosis !! Acanthosis !! Suprapapillary plate !! Granular cell layer changes !! Spinous cell layer changes !! Basal cell layer changes !! Other distinctive feature !! Micrograph !! Photograph
 |-
 ! Psoriasis
 | Present || Diffuse || Regular || Thin || Present || Decreased or absent || Increased mitoses; minimal spongiosis<br>Clubbed rete pegs<ref name="Kunz2009">{{cite journal|vauthors=Kunz M, Ibrahim SM |title=Cytokines and cytokine profiles in human autoimmune diseases and animal models of autoimmunity|journal=Mediators of Inflammation|year=2009|volume=2009|pages=1–20|pmid=19884985|pmc=2768824|doi=10.1155/2009/979258}}</ref> <ref name="Raychaudhuri2014">{{cite journal |vauthors=Raychaudhuri SK, Maverakis E, Raychaudhuri SP |title=Diagnosis and classification of psoriasis|journal=Autoimmunity Reviews|volume=13|issue=4–5|pages=490–5|date=January 2014 |pmid=24434359|doi=10.1016/j.autrev.2014.01.008}}</ref> || Absent
+|
+*Microabscesses
 | [[File:Micrograph of psoriasis vulgaris.jpg|120px]] || [[File:Psoriasis on elbow.jpg|120px]]
 |-
 ! Psoriasiform drug reaction
-| Present || Focal || Regular and irregular || Normal or thick || Absent || Normal || Spongiosis; eosinophilic infiltrate || Inflammatory cells; Civatte bodies
+| Present || Focal || Regular and irregular || Normal or thick || Absent || Normal || Spongiosis; eosinophilic infiltrate || Inflammatory cells; Civatte bodies ||
 |-
 ! Chronic allergic/contact and atopic dermatitis
-| Present || Focal; crust may be present || Irregular || Normal or thick || Absent || Normal || Spongiosis; eosinophilic infiltrate || Absent
+| Present || Focal; crust may be present || Irregular || Normal or thick || Absent || Normal || Spongiosis; eosinophilic infiltrate || Absent ||
 |-
 ! Fungal infection
-| Compact || Focal; crust may be present || Irregular || Normal or thick || Absent || Normal || Occasional neutrophiles; || –
+| Compact || Focal; crust may be present || Irregular || Normal or thick || Absent || Normal || Occasional neutrophiles; || Absent ||
 |-
 ! Lichen simplex chronicus
-| Present || Focal; thick crust || Regular or irregular || Thin or thick || Absent || Thickened; hypergranulosis || ±minimal inflammatory infiltrate || –
+| Present || Focal; thick crust || Regular or irregular || Thin or thick || Absent || Thickened; hypergranulosis || ±minimal inflammatory infiltrate || Absent ||
 |-
 ! Scabies
-| Present || Focal or diffuse || Irregular || Normal or thick || Absent || Normal || Inflammatory infiltrate; eosinophilic spongiosis || –
+| Present || Focal or diffuse || Irregular || Normal or thick || Absent || Normal || Inflammatory infiltrate; eosinophilic spongiosis || Absent ||
 |-
 ! Seborrheic dermatitis and HIV dermatitis
-| Present || Focal || Irregular || Normal or thick || Absent || Normal || Spongiosis; lymphocytic and neutrophilic infiltrate || –
+| Present || Focal || Irregular || Normal or thick || Absent || Normal || Spongiosis; lymphocytic and neutrophilic infiltrate || Absent ||
 |-
 ! Pityriasis rubra pilaris
-| Compact || Shoulder parakeratosis<ref group="notes">Parakeratotic mounds at the edge of follicular ostia.</ref>; alternating orthokeratosis and parakeratosis || Regular or irregular || Normal or thick || Absent || Normal || Spongiosis; lymphocytic infiltrate; rare acantholysis || Occasional vacuolar change
+| Compact || Shoulder parakeratosis<ref group="notes">Parakeratotic mounds at the edge of follicular ostia.</ref>; alternating orthokeratosis and parakeratosis || Regular or irregular || Normal or thick || Absent || Normal || Spongiosis; lymphocytic infiltrate; rare acantholysis || Occasional vacuolar change ||
 |-
 ! Pityriasis rosea
-| Present || Focal || Irregular || Normal or thick || Absent || Normal || Small foci of spongiosis; lymphocytic infiltrate || Occasional necrotic keratinocytes
+| Present || Focal || Irregular || Normal or thick || Absent || Normal || Small foci of spongiosis; lymphocytic infiltrate || Occasional necrotic keratinocytes ||
 |-
 ! Syphilis
-| Present || Focal || Regular or irregular || Normal or thick || Absent || Normal || Lymphocytes and neutrophils || Interface change
+| Present || Focal || Regular or irregular || Normal or thick || Absent || Normal || Lymphocytes and neutrophils || Interface change ||
 |-
 ! Pityriasis lichenoides chronica
-| Present || Caps of parakeratosis || Irregular || Normal || Absent || Normal || Mild spongiosis, lymphocytic infiltrate; necrotic keratinocytes || Necrotic keratinocytes
+| Present || Caps of parakeratosis || Irregular || Normal || Absent || Normal || Mild spongiosis, lymphocytic infiltrate; necrotic keratinocytes || Necrotic keratinocytes ||
 |-
 ! Mycosis fungoides
-| Present || Focal || Regular or irregular || Normal || Absent || Normal || Minimal or no spongiosis; ±Pautrier microabscess || Atypical lymphoid cells lining the dermo–epidermal junction
+| Present || Focal || Regular or irregular || Normal || Absent || Normal || Minimal or no spongiosis; ±Pautrier microabscess || Atypical lymphoid cells lining the dermo–epidermal junction ||
 | [[File:Histopathology of Pautrier microabscesses.jpg|thumb|120px|Pautrier microabscesses]]
 |}

Dermatitis: Difference between revisions

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