Evaluation of suspected malignancies: Difference between revisions
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{{General notes}} | {{General notes}} | ||
The most important aspects of a tumor is whether it is malignant or | The most important aspects of a tumor is whether it benign or malignant. If malignant, then staging is necessary.<ref name=cancer>{{cite web |url= http://www.cancer.gov/cancertopics/factsheet/detection/staging |title=Cancer staging |date= |publisher=National Cancer Institute |accessdate=4 January 2013}}</ref> | ||
==Benign or malignant== | |||
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! !! Benign<ref name=amboss>{{cite web|url=https://www.amboss.com/us/knowledge/General_oncology|title=General oncology|website=Amboss|accessdate=2020-01-29}}</ref> !! Malignant<ref name=amboss/> | |||
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! Gross examination | |||
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*Well demarcated from surrounding tissue | |||
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*Usually no tumor capsule | |||
Possibly: | |||
*Necrosis | |||
*Infiltration or invasion into surrounding tissue | |||
*Bleeding | |||
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! Microscopy | |||
| Almost no irregularities of cellular structures | |||
| Nuclear atypia: | |||
*Enlargement | |||
*Pleomorphism | |||
*Nuclear polychromasia, which means variability in nuclear chromatin content. | |||
*Numerous mitotic figures | |||
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==Staging== | ==Staging== | ||
Staging is generally done by TNM classification. Specific TNM systems should be used, as per the manual by the American Joint Committee on Cancer (AJCC), whenever applicable. Otherwise, a general system may be used:<ref name=cancer/> | |||
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