Evaluation of suspected malignancies: Difference between revisions

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{{General notes}}
{{General notes}}
The most important aspects of a tumor is whether it is malignant or not, and staging.
The most important aspects of a tumor is whether it benign or malignant. If malignant, then staging is necessary.<ref name=cancer>{{cite web |url= http://www.cancer.gov/cancertopics/factsheet/detection/staging |title=Cancer staging |date= |publisher=National Cancer Institute |accessdate=4 January 2013}}</ref>
 
==Benign or malignant==
{|class="wikitable"
!  !! Benign<ref name=amboss>{{cite web|url=https://www.amboss.com/us/knowledge/General_oncology|title=General oncology|website=Amboss|accessdate=2020-01-29}}</ref> !! Malignant<ref name=amboss/>
|-
! Gross examination
|
*Well demarcated from surrounding tissue
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*Usually no tumor capsule
Possibly:
*Necrosis
*Infiltration or invasion into surrounding tissue
*Bleeding
|-
! Microscopy
| Almost no irregularities of cellular structures
| Nuclear atypia:
*Enlargement
*Pleomorphism
*Nuclear polychromasia, which means variability in nuclear chromatin content.
*Numerous mitotic figures
|}


==Staging==
==Staging==
The primary focus of tumor evaluation is to distinguish benign from malignant types, and in case of malignancy the primary focus is to determine its stage, generally by the TNM classification:<ref>{{cite web |url= http://www.cancer.gov/cancertopics/factsheet/detection/staging |title=Cancer staging |date= |publisher=National Cancer Institute |accessdate=4 January 2013}}</ref>
Staging is generally done by TNM classification. Specific TNM systems should be used, as per the manual by the American Joint Committee on Cancer (AJCC), whenever applicable. Otherwise, a general system may be used:<ref name=cancer/>
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