Tophus: Difference between revisions
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== | ==Preparation== | ||
A tophus should be sent '''dry''' to the pathology department, and '''not'' be put in formalin.<ref group=notes>Formalin dissolves the crystals.</ref> | A tophus specimen should be sent '''dry''' to the pathology department, and '''not''' be put in formalin.<ref group=notes>Formalin dissolves the crystals.</ref> A touch prep can be done initially, and at least if urate crystals remain suspected, the specimen is submitted in 100% alcohol for microscopy evaluation. | ||
==Microscopy evaluation== | |||
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File:Uric acid crystals in polarized light.png|Uric acid crystals in polarized light, showing negative [[birefringence]], with yellow color when aligned parallel to the axis of the red compensator, and blue when aligned perpendicularly to it.<ref>{{cite web|url=https://emedicine.medscape.com/article/329958-workup|title=Gout and Pseudogout Workup|author=Bruce M Rothschild|website=Medscape}} Updated: Jun 30, 2020</ref> | |||
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