Tophus: Difference between revisions

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 ==Preparation==
-A tophus specimen should be sent '''dry''' to the pathology department, and '''not''' be put in formalin.<ref group=notes name=dissolves>Formalin dissolves the crystals.</ref> A touch prep can be done initially, and at least if urate crystals are not initially detected, the specimen is submitted in 100% alcohol for microscopy evaluation.<ref group=notes name=dissolves/>
+A tophus specimen should be sent '''dry''' to the pathology department, and '''not''' be put in formalin.<ref group=notes name=dissolves>Formalin dissolves the crystals.</ref>
 ==Gross processing==
 [[File:Gross pathology of tophus.jpg|thumb|A large tophus.]]
-Preferably make a touch prep, as well as take sections to be put in 100% alcohol and tell the histology lab to prepare it as per gout protocol.
+Preferably make a touch prep for polarized light microscopy. At least if urate crystals are not initially detected, take sections to be put in 100% alcohol and tell the histology lab to prepare it as per gout protocol.<ref group=notes name=dissolves/> With characteristic crystals on a touch prep, sections may possibly be submitted in formalin.<ref group=notes name=dissolves/>
 ==Microscopy evaluation==

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