Hepatocellular carcinoma: Difference between revisions
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[[File:Histopathology of moderately differentiated hepatocellular carcinoma.jpg|center|Moderately differentiated HCC.]] | |||
[[File:Histopathology of poorly differentiated hepatocellular carcinoma.jpg|thumb|Poorly differentiated HCC.]] | [[File:Histopathology of poorly differentiated hepatocellular carcinoma.jpg|thumb|Poorly differentiated HCC.]] | ||
*'''Poorly differentiated''': | *'''Poorly differentiated''': | ||
Revision as of 19:57, 21 December 2020
Author:
Mikael Häggström [note 1]
Presentations
Hepatocellular carcinoma is the most common diagnosis for liver tumors.:[1]
Microscopic evaluation
Hepatocellular carcinoma typically displays:[2]
- Trabecular pattern surrounded by layer of flattened endothelial cells.
- Presence of sinusoidal vessels surrounding tumor cells
- Scant stroma, and minimal desmoplasia
- Polygonal cells with distinct cell membranes
- Abundant granular eosinophilic cytoplasm
- Nuclei with increased N/C ratio, round nuclei with coarse chromatin and thickened nuclear membrane, and may have prominent nucleoli.
-
Needle biopsy. -
Needle biopsy. -
Needle biopsy. -
FNA. -
FNA clot section.
-
FNA clot section.
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Differentiation
Differentiations of hepatocellular carcinoma are:[2]
- Well differentiated:
- Thin plates (1 - 3 hepatocytes thick)
- Hepatocytes are smaller than normal
- Abnormal reticulin network
- Minimal nuclear atypia
- Nuclear density of 2x compared to normal liver
- Moderately differentiated:
- Trabecular pattern at least 4 cells thick
- Larger cells with more eosinophilic cytoplasm
- Distinct nucleoli
- Pseudoglands
- Poorly differentiated:
- Large tumor cells with hyperchromatic nuclei in compact growth pattern
- Rare trabeculae or bile
- Prominent pleomorphism
- May have spindle cell or small cell areas
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Table 37.2 in: Sternberg, Stephen (2012). Sternberg's diagnostic surgical pathology . Place of publication not identified: LWW. ISBN 978-1-4511-5289-0. OCLC 953861627.
- ↑ 2.0 2.1 Deepali Jain. Liver & intrahepatic bile ducts - Hepatocellular carcinoma - Hepatocellular carcinoma overview. PathologyOutlines. Topic Completed: 1 February 2012. Minor changes: 30 September 2020
Image sources