Immunohistochemistry: Difference between revisions
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In addition to EpCAM, GATA3 and p16, what is the best alternative, given the information you retrieved above, to differentiate lung versus anus squamous cell carcinoma? | In addition to EpCAM, GATA3 and p16, what is the best alternative, given the information you retrieved above, to differentiate lung versus anus squamous cell carcinoma? | ||
#DLK, and favor anus origin if having a diffusely membranous staining rather than diffusely cytoplasmic. | #Add DLK to the panel, and favor anus origin if having a diffusely membranous staining rather than diffusely cytoplasmic. | ||
#DLK, and favor anus origin if having a diffusely cytoplasmic staining rather than diffusely membranous. | #Add DLK to the panel, and favor anus origin if having a diffusely cytoplasmic staining rather than diffusely membranous. | ||
#GRPR, and favor anus origin | #Add GRPR to the panel, and favor anus origin if having either a diffuse or focal cytoplasmic staining. | ||
#GRPR, and favor anus origin | #Add GRPR to the panel, and favor anus origin if having a diffuse but not a focal cytoplasmic staining. | ||
#GRPR, and favor anus origin in focal but not diffuse cytoplasmic staining. | #Add GRPR to the panel, and favor anus origin in having a focal but not a diffuse cytoplasmic staining. | ||
;Correct answer | ;Correct answer | ||
[[File:GRPR answer.jpg| | [[File:GRPR answer.jpg|600px|left]]<br clear=all> | ||
GRPR is the top result when specifically comparing lung versus anus squamous cell carcinoma, both at sensitivity settings 1 and 3, with no major difference between them, and thus anus origin is favored in case of either diffuse or focal cytoplasmic staining. DLK showed as N/A for anus SCC. | |||
==Immunohistochemistry evaluation== | ==Immunohistochemistry evaluation== | ||