Template:IHC of MMR: Difference between revisions
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{{Moderate-begin}}Perform immunohistochemistry for MLH-1, PMS-2, MSH-2 and MSH-6.{{Moderate-end}} They are scored as:<ref>These cutoffs are used for both colorectal and endometrial cancers:<br>- {{cite journal|last1=Sarode|first1=Venetia R.|last2=Robinson|first2=Linda|title=Screening for Lynch Syndrome by Immunohistochemistry of Mismatch Repair Proteins: Significance of Indeterminate Result and Correlation With Mutational Studies|journal=Archives of Pathology & Laboratory Medicine|volume=143|issue=10|year=2019|pages=1225–1233|issn=0003-9985|doi=10.5858/arpa.2018-0201-OA}}<br>- {{cite journal| author=Sarode VR, Robinson L| title=Screening for Lynch Syndrome by Immunohistochemistry of Mismatch Repair Proteins: Significance of Indeterminate Result and Correlation With Mutational Studies. | journal=Arch Pathol Lab Med | year= 2019 | volume= 143 | issue= 10 | pages= 1225-1233 | pmid=30917047 | doi=10.5858/arpa.2018-0201-OA | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30917047 }}<br>- {{cite journal| author=Lee JHS, Li JJX, Chow C, Chan RCK, Kwan JSH, Lau TS | display-authors=etal| title=Long-Term Survival and Clinicopathological Implications of DNA Mismatch Repair Status in Endometrioid Endometrial Cancers in Hong Kong Chinese Women. | journal=Biomedicines | year= 2021 | volume= 9 | issue= 10 | pages= | pmid=34680502 | doi=10.3390/biomedicines9101385 | pmc=8533409 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=34680502 }}</ref> | <noinclude> | ||
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</noinclude>{{Moderate-begin}}Perform immunohistochemistry for MLH-1, PMS-2, MSH-2 and MSH-6.{{Moderate-end}} They are scored as:<ref>These cutoffs are used for both colorectal and endometrial cancers:<br>- {{cite journal|last1=Sarode|first1=Venetia R.|last2=Robinson|first2=Linda|title=Screening for Lynch Syndrome by Immunohistochemistry of Mismatch Repair Proteins: Significance of Indeterminate Result and Correlation With Mutational Studies|journal=Archives of Pathology & Laboratory Medicine|volume=143|issue=10|year=2019|pages=1225–1233|issn=0003-9985|doi=10.5858/arpa.2018-0201-OA}}<br>- {{cite journal| author=Sarode VR, Robinson L| title=Screening for Lynch Syndrome by Immunohistochemistry of Mismatch Repair Proteins: Significance of Indeterminate Result and Correlation With Mutational Studies. | journal=Arch Pathol Lab Med | year= 2019 | volume= 143 | issue= 10 | pages= 1225-1233 | pmid=30917047 | doi=10.5858/arpa.2018-0201-OA | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30917047 }}<br>- {{cite journal| author=Lee JHS, Li JJX, Chow C, Chan RCK, Kwan JSH, Lau TS | display-authors=etal| title=Long-Term Survival and Clinicopathological Implications of DNA Mismatch Repair Status in Endometrioid Endometrial Cancers in Hong Kong Chinese Women. | journal=Biomedicines | year= 2021 | volume= 9 | issue= 10 | pages= | pmid=34680502 | doi=10.3390/biomedicines9101385 | pmc=8533409 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=34680502 }}</ref> | |||
<gallery mode=packed heights=190> | <gallery mode=packed heights=190> | ||
File:Immunohistochemistry of loss of expression of MLH-1.jpg|0% nuclear expression in tumor cell nuclei: '''Loss of expression''' (expression seen in stromal cells in image) | File:Immunohistochemistry of loss of expression of MLH-1.jpg|0% nuclear expression in tumor cell nuclei: '''Loss of expression''' (expression seen in stromal cells in image) | ||